412799
Description
Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312
over 10 years ago
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Question 1
Question
What is the main difference between apoptosis and necrosis?
Answer
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In necrosis release of cell contents is controlled In apoptosis it's not
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In apoptosis release of cell contents is controlled In necrosis it's not
Question 2
Question
What protein condenses during apoptosis
Answer
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Chromatin
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Actin
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Myosin
Question 3
Question
What form are caspases usually found in?
Answer
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Inactive, with their DED domain tails intact
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Active, with their DED domain tails intact
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Inactive, with their DED domain tails removed
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Active, with their DED domain tails removed
Question 4
Question
What is required for caspase activation?
Answer
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Addition of a DED domain tail
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Removal of the DED domain tail
Question 5
Question
What are the roles of the 2 main caspases?
Answer
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3 is the initation 8 does most damage
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8 is the initiator 3 does most damage
Question 6
Question
Which of the following are survival/protector proteins that inhibit caspase activation?
Answer
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BAX, BAD, PUMA
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Bci-2, Mcl1, A1
Question 7
Question
What is required for ligand acitvated apoptosis?
Answer
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For the receptors to contain DED domains
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For the receptors to be bound to caspases
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For the receptors to be expressed only in certain areas of the cell membrane
Question 8
Question
What protein inhibits the activation of apoptic receptors?
Answer
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Flp
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Flr
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Fld
Question 9
Question
Name an apoptic receptor
Answer
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Fas
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Far
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Fam
Question 10
Question
How does the receptor activate caspase 8?
Answer
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By recruiting it and cleaving off the DED domain
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By recruiting it and adding a DED domain
Question 11
Question
Name the two methods caspase 8 uses to destroy the cell
Answer
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Activation of Caspase 3
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Deactivation of Caspase 3
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Damage to mitochondria, which releases Cyt. C
Question 12
Question
What does mitochondrial damage do to Casp 9?
Answer
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Activates it
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Deactivates it
Question 13
Question
What happens when essential growth factors are withdrawn from the cell?
Answer
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PI3K cannot activate
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PKB cannot activate
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Casp 8 cannot activate
Question 14
Question
How does PKB inhibit apoptosis?
Answer
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Releases Bad from Blc-2
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Releases Blc2 from Bad
Question 15
Question
Identify methods which cells can use to evade apoptosis
Answer
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Decreased Fas receptor expression
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Inc Blc2 & decrease bax/bad expression
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Loss of Casp 8
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Increased Flp expression
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Soluble fas to causes apoptosis in t-cells
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Large amounts of Fas ligand produced to kill t-cells
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