History of Microbiology

1st Microbiology
1. Antonie van Leeuwenhoek
  1. ~1st Handcrafted Microscope
  2. 1st Observation microbe refer Animalcules
Invention of microscope
1. Robert Hooke
2. Micrographia: Book describes microscopic world
Theories
1. 1.Spontaneous Generation
  1. Life arise non-living matter
    1. John Needham
      1. Experiment: Heat nutrient fluid before pour covered flask
        Discovery: Have microbes
      2. Theory: Microbe arise spontaneous
    2. Lazzaro Spallanzani
      1. Experiment: Same as Needham's
        Discovery: Contradict with Needham's.
        No microbes
      2. Theories:
        microbes from air enter into Needham's flask
  2. Problems:
    1. Needham said Spallanzani has not enought O2 to support microbial life
      1. Due to extend boiling
2. 2.Biogenesis
  1. Living cells arise from pre-existing living cell
  2. Rudolf Virchow
3. 3.Pasteur's Experiment
  1. Experiment:
    1. Boiled beef broth in sealed and opened short flask
      1. Discovery: Sealed flask=No microbe
    2. Boiled open-ended "S" flask bent filled broth
      1. Discovery: No microbe
  2. Theories
    1. Curved neck ("S") trapped airborne microbes
    2. Microbes is everywhere
    3. Microbe destroyed heat
    4. Method devised: block access airborne microorganism to nutrients environment
Golden Age Of Microbiology
1. Discovery:
  1. Agent of many diseases
    1. Germ Theory Disease
      1. Robert Koch
        Discovered Bacillus anthracis
        Koch's postulated
  2. Role Immunity in prevention & cure
  3. Study chemical activities microorganism
  4. Improve techniques performing microscope and cultured microbes
  5. Vaccine Developments and surgical techniques
    1. Edward Jenner
      1. Inoculate attenuated (weak) virus in his own son (Swine pox and smallpox)
        1st vaccine

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History of Microbiology

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