Genetic Engineering Benefits and Concerns

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Degree FAHAW Mindmap am Genetic Engineering Benefits and Concerns, erstellt von jamesryeomans am 23/05/2013.
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Zusammenfassung der Ressource

Genetic Engineering Benefits and Concerns
  1. Introduction
    1. Genetic engineering can be the direct manipulation of an organisms genome using biotechnology or the indirect modification through artificial selection
      1. This essay will discuss the most relavent aspects of genetic engineering and assess the benefits, limitations and concerns of using genetic engineering to improve animal, health, disease defence
        1. Firstly the previous methods of genetic engineer ing will be initially discussed, moving on to the current available biotechnologies and finally consider the future potential of these technologies
        2. Selective Breeding
          1. Selective breeding has been used for over 2000 years to select animals with desired traits based on phenotypic expression,
            1. Improve Health
              1. Breeding to produce homozygosity of desired traits
                1. Foot angle to reduce lameness
                2. "NZ" style easycare systems
                  1. Sheep
                    1. Foot rot
                      1. Worms
                  2. Desireable traits
                    1. Dairy cows are typical example of selective breeding with highest yielding cows bred to high yield (daughter) producing bulls
                      1. Benefits
                        1. More yield per cow (profitable)
                          1. Environmental/ feed the world/less cows required
                          2. Negatives
                            1. Irresponsible selection
                              1. Deleterious traits
                                1. Lameness
                                2. Poor fertility
                                  1. Nutrient partitioning
                                  2. Maybe inadvertedly selecting for deleterious triats
                                3. Increased production
                                  1. FCR
                                    1. Fertility
                                      1. Growth
                                    2. AI/MOET
                                      1. Increase selection intensity
                                        1. Spread genes worldwide rapidly
                                          1. Cover more animals
                                            1. Reduce population variance
                                          2. Gene Identification
                                            1. Genes can now be identified to detect deleterious genes
                                              1. 1) Gene code identified e.g. Mastitis suceptibility
                                                1. 2) Opposite code created and marked with flourescence
                                                  1. 3) Code binds at site of gene if present
                                                  2. Genomics allows selection of more suitable parents
                                                    1. Select against weaknesses
                                                      1. Reduce inbreeding
                                                        1. Avoid homozygosity of traits and genes e.g. halothane gene in pigs
                                                          1. Porcine Stress syndrome
                                                            1. Sudden death
                                                              1. Pale soft exudative meat
                                                                1. Acid meat from anaerobic muscle etabolism decreasing muscle quality
                                                                2. Back muscle necrosis
                                                                3. Reduce generation gap in cows
                                                                  1. More rapid prduction of offspring
                                                              2. Genetic engineering
                                                                1. Genetic engineering is the process of changing the phenotype through expression of introduced DNA, addition, deletion or substitution of the animals own DNA
                                                                  1. Techniques used
                                                                    1. Pro-nuclear micro injection
                                                                      1. Inject genetic material into the nucleus of oocyte
                                                                        1. Over expression
                                                                          1. If not icorporated into germline it wont be passed to next generation
                                                                          2. Stem cell manipulation
                                                                            1. Nuclear transfer (cloning)
                                                                          3. Concerns
                                                                            1. Mutagenesis
                                                                            2. Benefits
                                                                              1. Improving animal health and fighting disease
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