11953541
Beschreibung
Mindmap von Gelöschter Nutzer, aktualisiert more than 1 year ago
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Erstellt von Plymouth Med
vor fast 7 Jahre
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Kopiert von Plymouth Med
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Neuromuscular
Junction
- Terminal
Axon
- Motor End Plate of Muscle
Fiber
- 4) Receptors open up ligand-gated cation channels
- 5) Depolarization of sarcolemma membrane
via t-tubules
- Sodium ions enter muscle
fiber
- Potassium ions leave muscle
fiber
- goes from -70 mv--> +40
mv
- 6) Action potential fired along length of the muscle
fiber
- travels length of the myotube
- travels length of the myotube
- 6) Action potential fired along length of the muscle
fiber
- Sodium ions enter muscle
fiber
- 5) Depolarization of sarcolemma membrane
via t-tubules
- Muscle fiber/myotube
- Sarc.
Reticulum
- Storage of calcium
ions
- Resting muscle = HIGH
[Calcium]
- ATP-fueled CA2+
pumps/channels
- Resting muscle = HIGH
[Calcium]
- Storage of calcium
ions
- Sarcoplasm (membrane)
- Myofibril
- Made of 2
myofilaments
- Cross Bridge
Interaction
- Actin
- Has myosin binding
sites
- Thick
strand
- Has myosin binding
sites
- Myosin
- Double Headed,
Thin strand
- covered by Tropomyosin
- Calcium binding sites
- Calcium binding sites
- Myosin heads activated via ATP
- ATP from Creatine Phosphate
- most abundant source of ATP for skeletal muscles
- Enzyme Creatine Kinase
- Break phosphates into ATP
- Build ATP back up together
- Break phosphates into ATP
- most abundant source of ATP for skeletal muscles
- Break it into ADP and P
- Muscle chance to relax
until ATP formed again
- Muscle chance to relax
until ATP formed again
- ATP from Creatine Phosphate
- Double Headed,
Thin strand
- Actin
- Cross Bridge
Interaction
- Made of 2
myofilaments
- Sarc.
Reticulum
- t-tub
- 7) take action potential
deep into the
individual muscle cells
- 8) Causes sarcoplasmic
Reticulum to release
calcium into sarcoplasm
- DHP receptors cause
release of calcium
- DHP--> voltage-dep calcium channel
- DHP--> voltage-dep calcium channel
- 9) Calcium rushes off and binds to tropomyosin
- Conformational Change
- 10) Tropomyosin moves away
- 11) Actin binds to Myosin
- Actin pulls itself along=
MUSCLE CONTRACTION
- Contraction END:
when Calcium ions
actively transported
back to sarcoplasmic
reticulum
- Contraction END:
when Calcium ions
actively transported
back to sarcoplasmic
reticulum
- Actin pulls itself along=
MUSCLE CONTRACTION
- 11) Actin binds to Myosin
- 10) Tropomyosin moves away
- Conformational Change
- DHP receptors cause
release of calcium
- 8) Causes sarcoplasmic
Reticulum to release
calcium into sarcoplasm
- 7) take action potential
deep into the
individual muscle cells
- 4) Receptors open up ligand-gated cation channels
- Motor End Plate of Muscle
Fiber
- Neuron
- 1) Action Potential
arrives From Neuron
- 2) CA 2+ ions diffuse into the dendrite
- go into presynaptic end
- via open voltage-gated calcium
channels
- via open voltage-gated calcium
channels
- Calcium influx
- synaptic vesicles ready to fire
AcH
- AcH released into the synaptic cleft
- released via
exocytosis
- 3)Diffuses across and binds to receptors on motor end plate
- presynaptic AcH binding-->
+ feedback loop
- preps more Ach release
- sustain/more muscle contraction
- AcH
removal
- Reuptake
- Diffuses back across
cleft
- Diffuses back across
cleft
- Broke down
- Acetylcholinesterase
- Acetyl
Acid
- Choline
- Acetyl
Acid
- Acetylcholinesterase
- Reuptake
- sustain/more muscle contraction
- preps more Ach release
- presynaptic AcH binding-->
+ feedback loop
- 3)Diffuses across and binds to receptors on motor end plate
- released via
exocytosis
- synaptic vesicles ready to fire
AcH
- go into presynaptic end
- 2) CA 2+ ions diffuse into the dendrite
- 1) Action Potential
arrives From Neuron
- All muscle types use
calcium and ATP for
contraction
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