Zusammenfassung der Ressource
Diabetic nephropathy
- Anatomy of the kidney
- Blood supply
- Histology of the kidney
- Physiology of glomerular filtration
- Clearance
- Volume of plasma cleared of the substance by the kidney in one minute
- C ml/min (Clearance) = U x V / P
- Glomerular
filtration rate
- the clearance of a substance freely
filtered at the glomerulus but not
reabsorbed or secreted in the tubules
- Pathological features and types of glomerular diseases
- Nephritic syndrome
- Post streptococcal GN
- Rapidly progressive GN (crescentic)
- IgA nephropathy
- SLE
- Alport syndrome
- Nephrotic syndrome
- Primary
- Secondary
- SLE
- Diabetes
- Pathogenesis
- 1. High serum glucose levels lead to hyaline
arteriolosclerosis in efferent arteriole
- 2. high GFR and microalbuminuria
- 3. progress to sclerosis of the mesangium of
the glomerulus and nephrotic syndrome
- Amyloidosis
- Complications
- hypertention
- Acute kidney failure
- Chronic kidney failure
- Renal function tests
- Serum Blood Urea Nitrogen (BUN) – 7-18 mg/dL
- Serum Creatinine – 0.6-1.2 mg/dL
- Serum BUN/Creatinine ratio - 15
- Creatinine Clearance (CCr) – 97-137 mL/minute
- Urinalysis
- Treatment
- Diuretics
- Thiazide diuretics
- Loop diuretics
- Potassium sparing diuretics
- carbonic anhydrase inhibitors
- Osmotic diuretics
- Kidney transplantation