I always feel tired

Blood
1. Hematopoiesis
  1. Location
    1. very early embryo
      1. Yolk Sac
    2. Middle Trimister
      1. Liver, Spleen
    3. CHILDHOOD
      1. Red bone marrow
    4. ADULT
      1. Red and yellow bone marrow
  2. Erythrocyte Differentiation
  3. Regulation
    1. Thyroid hormones
    2. Glucocorticoids
    3. Androgens
    4. erythropoietin
2. HB structure
Anemia
1. Risk factors
  1. Diet
  2. Intestinal disorders.
  3. Menstruation
  4. Pregnancy
  5. Age
  6. Family history.
2. Causes
3. Signs and Symptoms
  1. fatigue
  2. tachycardia
  3. Pale skin
  4. dizziness
  5. pica
4. Types
  1. Iron deficiency anemia
  2. megaloblastic
  3. Anemia of chronic disease
  4. Aplastic
  5. Sickle cell anemia
  6. Hemolytic
5. Complications
  1. Severe fatigue
  2. Pregnancy complications
  3. Heart problems
  4. Vaso-occlusion
  5. Respiratory
  6. Death
6. Investigations
  1. Cardiac
    1. Arrhythmia
    2. Palpitation
    3. blood pressure
    4. cardiac output
  2. Respiratory
    1. Shortness of breath
    2. Tachypnea
  3. Liver and kidney function
  4. Laboratory tests
    1. CBC
    2. Peripheral smear
    3. HB electrophoresis
    4. Iron studies
      1. Serum iron
      2. TIBC
      3. Iron saturation
      4. Serum ferritin
  5. Blood film
7. DRUGS
  1. Iron deficiency anemias
    1. elderly
      1. red cell transfusions
    2. Youth
      1. iron replacement
        oral
        parentral
        iron
        dextran
        sucrose
        Adverse effects
        GI distress
        Hypersensitivity
  2. Erythropoietin
  3. Sideroblastic anemia
    1. vitamin B6
  4. Thalassemia
    1. Blood transfusion
    2. Marrow transplant
  5. megaloblastic anemia
    1. Vitamin B9\leucovorin
8. Epidemiology
  1. Cause of 68.4m YLD for women
  2. prevalence
    1. developed countries
      1. 14%
    2. developing countries
      1. 51%

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I always feel tired

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