Zusammenfassung der Ressource
Antiphospholipid
syndrome
- Cause
- autoimmune
- ?antiphospholipid antibodies
- lupus
anticoagulant
- anti-cardiolipin
- anti-β2-glycoprotein-I
- complement
and platelet
activation
- genetic
- unknown
- presentation
- hypercoagulable state
- venous
- DVT
- PE
- arterial
- stroke
- pregnancy complications
- stillbirth
- miscarriage
- preterm
delivery
- severe
pre-eclampsia
- Livedo reticularis
- haemolytic
anaemia
- thrombocytopenia
- Types
- Primary
- HLA-DR7
- Secondary
- risk factors
- associated with
other
autoimmune
diseases e.g. SLE, RA
- HLA-B8,
HLA-DR2,
HLA-DR3
- ethnicity
- most
common in
young
fertile
women
- Management
- Lifestyle to
reduce
cardiovascular
risks
- Thrombosis risk
- Acute
- Heparin
- Long term
- Warfarin (INR 2-3) or antiplatelet
- In pregnancy
- LMWH + aspirin