ABPI Chemotherapy

Cytotoxic agents - Bind to DNA
1. Alkylating agents - Damage DNA (damage bone & GI)
  1. Cyclophosphamide
    1. Chlorambucil
      1. Melphalan
      2. Busulfan
        Lomustine
        Bendamustine
2. Cytotoxic antibiotics -Stick to DNA
  1. Doxorubicin (DNA & RNA)
    1. Dactinomycin
      1. Bleomycin
        Mitomycin
3. Antibetabolites - Block DNA
  1. Methotrexate (Leukaemia)
4. Vinca alkaloids -Madagascar periwincle
  1. Vinblastine
    1. Vincristine
      1. Vinorelbine
        Vindesine
5. Taxanes -Pacific Yew tree
  1. Paclitaxel (Ovarian)
    1. Docetaxel
Cytokines - interferons & interleukins
Hormone-related
1. Anastrazole
  1. Exemestane
    1. Fulvestrant
      1. Tamoxifen
Radioimmunotherapy agents
Immunomodulators
Other chemo treatments
1. Platinum compounds
  1. Carboplatin (Ovarian)
    1. Cisplatin (Cervical)
2. Monoclonal antibodies
  1. Ofatumumab
    1. Alemtuzumab
      1. Rituximab
        Trastuzumab (HER2 -Breast)
        Cetuximab
        Bevacizumab
3. Targeted molecular therapies
  1. Protein kinase inhibitors
    1. Dasatinib
      1. Erlotinib
      2. Everolimus
        Gefitinib
        Imatinib
        Lapatinib
        Nilotinib
        Pazopanib
        Sunitinib
4. Topoisomerase 1 inhibotors
  1. Irinotecan
    1. Topotecan

Zusammenfassung der Ressource

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