Zusammenfassung der Ressource
Beta-Lactams
- Penicillins
- PENICILLIN G
- Repository
Anmerkungen:
- All routes
- PENICILLIN V
- Oral only
- Inhibit transpeptidases
- Activate autolysins
- NOT effective against
dormant bacteria
Anmerkungen:
- Gram+
Anmerkungen:
- Broad spectrum also kill gram-
- Kill cocci, syphilis, Bacillis anthracis
- Resistance
- beta-lactamases
Anmerkungen:
- inactivate the antibiotic by cleaving the beta-lactam ring
- Penicillinase-resistant
penicillins
- NAFCILLIN
- OXACILLIN
- DICLOXACILLIN
- CLOXACILLIN
- PBPs w/ low affinity
for antibiotic
- Gram-
Anmerkungen:
- AMPICILLIN
- G- meningitis
- CARBENICILLIN
- Pseudomonas,
ampicillin-resistants
- Lipophilic side chains
- Allergy,
heart failure
Anmerkungen:
- Allergy acute/accelerated/delayed. Acute = anaphylaxis
Heart failure from sodium salts
- Excreted
- Cephalosporins
- No repository form
- Inhibit transpeptidases
- Kill gram+ cocci, gram- bacilli
- Resistance
- Cephalosporinases
- Can use against
penicillin-resistant bacteria
- 1st Gen
- Inexpensive
- Surgery prophylaxis
- CEFAZOLIN
- 2nd Gen
- For stuff resistant
to penicillin
- 3rd Gen
Anmerkungen:
- Gram- meningitis
Anmerkungen:
- Gonorrhea
- 4th Gen
- CEFEPIME
- Penetrates CSF
- Haemophilus,
Neisseria
- Treat klebsiella
- Allergy, bleeding
disorders
Anmerkungen:
- More susceptible if allergic to penicillins
Reverse bleeding with vitamin K
- Alcohol
Anmerkungen:
- Can cause disulfiram reactions
- 5th Gen
- Ceftaroline
- MRSAs
- Monobactams
- Made by G- bacteria
- AZTERONAM
- Against G-
Anmerkungen:
- pseudomonas, serratia, e. coli
- NOT against G+
- Made by fungi
Anmerkungen:
- Carbapenems
- IMIPENEM
- Used for serious infections
Anmerkungen:
- Use with CILASTATIN
Anmerkungen:
- Stops metabolism in renal tubule
- Seizures
- Beta-lactamase Inhibitors
- Potentiate antibiotics, prevent breakdown
- CLAVULANIC ACID
- SULBACTAM, TAZOBACTAM