Endocrine System Drugs

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Endocrine System
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Zusammenfassung der Ressource

Endocrine System Drugs
  1. Diabetes
    1. Type 1
      1. Caused by autoimmune attack against the pancreatic beta cells. Prevalent in children. .
        1. Treatment: Insulin replacement therapy
      2. Type 2
        1. Insensitivity of cells to insulin signaling. Developes from long term environmental factors such as, a sedentary lifestyle, and being overweight/obese.
          1. Treatment: Exercise and dietary changes to promote weight loss, medications, and hormone therapy,
        2. Gestational
          1. Insensitivity of cells to insulin signaling during pregnancy occurs when the normal insulin resistance that occurs in pregnancy becomes excessive and leads to hyperglycemia in the mother.
            1. Treatment: Blood glucose monitoring, dietary changes, exercise, weight gain limitations, and cesarian delivery
          2. Types of Insulin: - Rapid acting - short acting - intermediate acting - long acting
            1. IV (only administered in emergencies), intermittent subcutaneous injection, or by continuous infusion pump
            2. Treatment for hypoglycemia: Consume 15-20 grams of glucose or simple carbohydrates. Recheck your blood glucose after 15 minutes. If hypoglycemia continues, repeat. Once blood glucose returns to normal, eat a small snack if your next planned meal or snack is more than an hour or two away.
            3. Thyroid disorders
              1. Hyperthyroidism
                1. Radioactive iodine, Anti-thyroid medications, Beta blockers, Surgery (thyroidectomy).
                2. Hypothyroidism
                  1. synthetic (man-made) thyroid hormone T4.
                3. Oral hypoglycemic (Type 2 diabetes)
                  1. Insulin secratogogues, insulin sensitizers, a-glucosidase inhibitors, glucagon-like peptide agonists
                    1. Adverse effects: Hypoglycemia, wt gain
                      1. Increases insulin cell receptors, increases abil of cell to bind insulin
                      2. Adrenal disorders
                        1. Addisons disease
                          1. Hormone replacement. Prednisone (replace cortisol), fludrocortisone (replaces aldosterone)
                          2. Cushings disease
                            1. Remove causative drug, surgery, radiotherapy
                            2. Conn's disease
                              1. Removal of tumor, adrenalectomy Meds: spironolactone (Aldactone) eplerenone (Inspra) amiloride (Midamor)
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