RHEUMATOID ARTHRITIS

Beschreibung

Mindmap am RHEUMATOID ARTHRITIS, erstellt von Marwa Alqassim am 14/02/2022.
Marwa Alqassim
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Marwa Alqassim
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Zusammenfassung der Ressource

RHEUMATOID ARTHRITIS
  1. autoimmune disease caused by loss of self-tolerance
    1. 1- Bystander T cell activation
      1. 2- Molecular mimicry
        1. 3- Polyclonal lymphocyte activation
          1. 4- Altered self
            1. 5- Release of sequestered antigens
              1. 6- Availability of cryptic epitopes
    2. Pathogenesis
      1. Investigations
        1. X-ray ,MRI
          1. Anti CCP , RF
            1. clinical examination
            2. Complications
              1. Managment
                1. Pharmacological
                  1. DMARDs
                    1. NSAIDs
                      1. Corticosteroids
                        1. Biologic therapies
                  2. Non-Pharmacological
                    1. Exercise
                      1. Relax
                        1. Surgery
                      2. prognosis
                        1. depends on
                          1. age , symptoms , disease condition
                        2. Epidimelogy
                          1. Psychological Effect
                            1. affects
                              1. Hand
                                1. Examination
                                  1. Inspection,Palpation, and ROM
                                    1. Phalen’s . Tinel’s , Finkelstein’s tests
                                  2. Bones
                                    1. carpals , metacarpals , phalanges
                                    2. Joints
                                      1. Swollen Joints
                                        1. acute
                                          1. chronic
                                            1. Osteoarthritis
                                              1. Rheumatoid Arthritis
                                                1. Gout
                                              2. wrist , carpal , CM , MP , IP
                                                1. all are synovial
                                                  1. Synovial Fluid
                                                    1. contains
                                                      1. Water , Inorganic salts Hyaluronic acid ,Lubricin
                                                        1. Neutrophils ,Lymphocytes Monocytes, Macrophages
                                                2. Intrinsic Muscles
                                                  1. thenar , hypothenar , lumbricals , interossei , palmaris brevis , adductor pollicis
                                                  2. Blood Supply
                                                    1. superficial & deep arches
                                                    2. Nerves
                                                      1. ulnar , median , radial
                                                  3. Infertility
                                                    1. not being able to get pregnant (conceive) after 1 year of unprotected sex
                                                      1. Causes
                                                        1. Women
                                                          1. PCOS
                                                            1. Endometriosis
                                                              1. Ovulation disorders
                                                          2. Men
                                                            1. Varicocele
                                                              1. Undescended testes
                                                                1. Abnormal sperm production or function
                                                          3. Risk factors
                                                            1. Age
                                                              1. Alcohol
                                                                1. Smoking
                                                                  1. Stress
                                                                    1. Radiation therapy
                                                            2. Types
                                                              1. Primary
                                                                1. Secondary
                                                                2. Pathophysiology
                                                                  1. Investigations
                                                                    1. Blood test
                                                                      1. Hormone studies
                                                                        1. Sperm antibodies
                                                                          1. Ultrasound
                                                                    2. Management
                                                                    3. Anatomy
                                                                      1. Histology
                                                                      Zusammenfassung anzeigen Zusammenfassung ausblenden

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