Zusammenfassung der Ressource
Exam 2: Second-Generation Sulfonylureas
- Nursing interventions
- Intermittent glucose monitoring
- Obtain baseline BUN, Cr, and LFTs
- Continue monitoring
BUN and Cr if over 65
- Pharmacological Action
- Stimulates release of
insulin from the pancreas
- Extra information
- Less effective over time
- Taken 30 minutes before
breakfast
- Pharmokinetics
- Excreted through urine
- Metabolized in the liver
- Adverse effects
- Hypoglycemia
- Nausea
- Heartburn
- Photosensitivity
- Contraindications
- Sulfa allergy
- Hepatic/Renal Impairment
- Pregnancy/Lactation
- Diabetic ketoacidosis
- Drug interactions
- Beta-blockers (suppress
insulin release)
- Disulfiram-like reaction
- Drugs that can interact to cause hypoglycemia
- sulfonamide antibiotics
- Acute alcohol ingestion
- NSAIDs
- cimetidine (Tagamet)