Zusammenfassung der Ressource
Adrenergic Agonists
- Catecolamines
- Rapid inactivation (COMT/MAO), cannot
be taken orally. Poor CNS penetration.
- Epinephrine, Norpeinephrine, Dopamine
- Affects sympathetic NS through adrenoreceptors
- Non-catecolamines
- Long half-life (slow MAO), can be
taken orally. Penetration into CNS.
- Ephedrine
- Direct acting
- Epinephrine
- Alpha1, 2 Beta 1, 2
- Alpha 1 (vasoconstriction) – delays absorption of
anaesthetics, control superficial bleeding, increase BP
Beta 1 – overcome AV heart. Beta 2 – bronchodilation
- Hypersensitive crisis (↑ BP), Dysrhythmias,
Angina Pectoris, Hyperglycaemia
- Dopamine
- Alpha and Beta
- Cardiogenic and septic
shock, raises BP and
increases cardiac output.
Enhances kidney and
splancnic perfusion
- Indirect acting
- Amphetamines
- Enhance E and EN
- Stimulatory (E/NE), increase BP
through release of Dopamine and NE
- Mixed
- Ephidrine
- Release stored NE and stimulate α
and β receptors. Vasoconstriction,
bronchodilation.
- 1. Direct receptor binding
- 2. Promote NE release
- 3. Inhibit NE reuptake
- 4. Inhibition of NE inactivation (MAO)
- Receptors
- α1
- Eyes, blood vessels,
male sex organs,
prostatic capsule,
bladder
- α2
- β1
- Heart, kidney
- β2
- Blood vessels,
bronchi, GIT, liver,
skeletal muscle