Dopamine Pathways in the brain by Tosin

1. Motivation, Emotion, REWARD!

   Anmerkungen:

   • Regulates these behaviours
   1. Overactivity = Positive Symptoms of Szh

      Anmerkungen:

      • These include Delusions, Hallucinations and Thought Disorder and other Psychosis (reality testing is impaired) Furthermore = Catatonia (immobility/ non-purposeful movement)

Anmerkungen:

• Underactivity of this results = Antipsychotic Drug MOA

1. Dorsal Lateral PFC = Cognitive Functions
   1. Cognitive Deficits in Szh
2. Ventral Lateral PFC = Emotions and Affect
   1. Overactivity = Negative Symptoms of Szh

1. Controls Movement indirectly - Overactivity = Tardive Dyskinesia & Underactivity = Parkinsonism

   Anmerkungen:

   • See Basal Ganglia Pathways! Involved in preventing non-purposeful movement
   • Parkinsonism = Movement disorder & clinical syndrome caused by lesions/damage to Basal ganglis'a Substantia Nigra

Anmerkungen:

• In particular the Extrapyramidal side effects = movement disorders
• These disorders involve involuntary movements 

Anmerkungen:

• From one part of the hypothalamus to the other
• Portal circulation between Medial eminence and Anterior pituitary = Dopamine released here
• Dopamine inhibits Prolactin release

1. Hyperactivity = Too little Prolactin
2. Underactivity = Too much Prolactin

   Anmerkungen:

   • So D2 Blockade = Hyperprolactineamia
   • This is another side effect of Antipsychotic Drugs