Zusammenfassung der Ressource
INTRO TO PATHOLOGY
- Study of disease from a molecular level to effects on individual
- Goal is the identification of causes and prevention and treatment
- When cells are exposed to noxious physical, chemical they become injured
- cells respond to stimuli by getting bigger, smaller, proliferate or die
- CHARACTERISTICS OF DISEASE
- AETIOLOGY - cause
- PATHOGENISIS - mechanism causing disease
- CLINICAL MANIFESTATIONS - functional feature
- COMPLICATIONS/SEQUALE -systemic consequences
- PROGNOSIS - anticipated course ie cure or fate
- EPIDEMIOLOGY - population distrubution
- AETIOLOGY
- Genetic abnormalities
- Infective agent - bacteria, virus, fungi
- Chemicals, Radiation, Mechanical trauma
- Multifactorial causes
- DISEASE OF UNKNOWN CAUSE
- Classified as idiopathic, spontaneous, cryptogenic
- Arising from the body its self - process inside the body
- HOST PREDISPOSITION
- Nutritional status, genetic, pre-existing immunity
- PATHOGENISIS
- Common pathways:
- INFLAMMATION: tissue injury response to harmful stimuli
- DEGENERATION:deterioration to cells in response to agents
- CARCINOGENISIS:agents resulting in tumour formation
- IMMUNE REACTIONS
- LATENT INTERVALS AND INCUBATION PERIOD
- LATENT: 2/3 decades - carcinogenisis
- INCUBATION:days/weeks infectious bacteria or virus
- STRUCTURAL/FUNCTIONAL MANIFESTATIONS
- Cause of disease produces clinical signs and symptoms
- PATHOLOGICAL:are structural abnormalities evident through microscope
- STRUCTURAL
- TUMOURS:displace and destroy surrounding tissue
- DEPOSITION OF ABNORMAL MATERIAL:amylodosis
- ABNORMALLY SITED TISSUE: metastasis (spread)
- LOSS OF TISSUE: ulcer or in an organ - infarction
- OBSTRUCTION:asthma, vessel
- RUPTURE OF HOLOW TUBE:aneurysm, perforation
- FUNCTIONAL
- EXCESSIVE SECRETION:of cell product ie hormone, mucus
- INSUFFICIENT SECRETION:diabetes (insulin)
- IMPAIRED NERVE FUNCTION:neuropathy
- IMPAIRED MUSCLE FUNCTION:myopathy