Zusammenfassung der Ressource
C3
- iC3
- D Cleaves B into Ba and Bb
- Ba is released
- Bb + iC3 = iC3b
- iC3b
- cleaves C3 into C3a and C3b
- C3b attaches to pathogen
- D cleaves B into Ba and Bb
- C3b + Bb = C3bBb
- alternative C3
convertase
- alternative C5
convertase
- C3b2Bb
- Cleaves C5 into C5a and C5b
- C5b initiates membrane-attack complex
- C6, C7, C8 bind
- C9 polymerizes
- C5a
- Analphylatoxins
- + C3b
- Ba is released
- B
- C3a
- classical C3 convertase
- C4bC2a
- C2a
- C2
- C2b
- C4b
- C4
- cleaves
- MASP2
- Lectin Pathway
- C1s
- CRP
- binds to C1q
- C1r cuts itself
- C1r cuts other C1r
- <-- C1r cuts both C1s
- C1s
- Classical Pathway
- C4a
- Anaphylatoxins
- soluble C3 convertase
- B
- Hydrolysis