5214056
Beschreibung
Mindmap von zarithsofea1303, aktualisiert more than 1 year ago
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Erstellt von zarithsofea1303
vor mehr als 8 Jahre
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INTRODUCTION
TO
IMMUNOLOGY
- COMPONENTS OF
THE 'IS'
- CARDIOVASCULAR
SYSTEM
- Heart and
Blood
- Heart and
Blood
- MONONUCLEAR PHAGOCYTE
SYSTEM
- Network of Reticular Fibres
- Phagocytes (ESP
macrophages)
- Network of Reticular Fibres
- LYMPHATIC
SYSTEM
- Organ of the Lymphatic System
- PRIMARY LYMPHOID ORGANS
-production sites of immune cells
-maturation sites (absence of antigens)
- Bone marrow
- Thymus
- Bone marrow
- SECONDARY LYMPHOID ORGANS
-maturation sites for antigen-driven
immune cells
- Adenoid
- Tonsils
- Lymph nodes
- Spleen
- MALT
- Adenoid
- LYMPH CIRCULATORY
SYSTEM
- Lymphatic vessels
- Lymphatic vessels
- PRIMARY LYMPHOID ORGANS
-production sites of immune cells
-maturation sites (absence of antigens)
- Organ of the Lymphatic System
- CARDIOVASCULAR
SYSTEM
- CELLS OF THE
'IS'
- Leukocytes
- Have nuclei
- Involved in phagocytosis, inflammation and adaptive immune response
- Have nuclei
- Platelets
- Do not have nuclei
- Involved in inflammation and bloood clotting
- Do not have nuclei
- Leukocytes
- INNNATE
IMMUNITY
- 2ND LINE OF DEFENCE (PHYSIOLOGICAL BARRIERS)
- Fever
- > 37 degree celcius
- initiated by PYROGENS
- BENEFITS
- reduced iron availability
- inhibition of microbial multiplication
- increase metabolic rate
- reduced iron availability
- > 37 degree celcius
- Inflammation
- Symptoms
- Redness ( increased RBC )
- Heat ( increased blood flow )
- Pain ( stimulation of nerve endings )
- Oedema ( swelling )
- Redness ( increased RBC )
- Stages
- 1. Tissue injury by release
chemical signals (HISTAMINE)
2. Dilation and increased
leakiness of local blood vesssels.
3. Phagocytes consume bacteria
and cell debris
- 1. Tissue injury by release
chemical signals (HISTAMINE)
2. Dilation and increased
leakiness of local blood vesssels.
3. Phagocytes consume bacteria
and cell debris
- Release of cytokines
- Vasodilation
- Symptoms
- Phagocytosis
- 1. Attachment
- 2. Ingestion
- 3. Killing
- 4. Degradation
- 1. Attachment
- Antimicrobial proteins
- Complement System
- 3 pathways : classical, lectin and alternative
- 3 pathways : classical, lectin and alternative
- Interferons
- 3 major types : IFN-alpha, IFN-beta, IFN-gamma
- 3 major types : IFN-alpha, IFN-beta, IFN-gamma
- Iron-binding Proteins
- SIDESPHORES (to steal iron from host proteins)
- SIDESPHORES (to steal iron from host proteins)
- Antimicrobial peptides
- Eg. Bacteriocins, Defensins, Magainins, Protegrins
- Eg. Bacteriocins, Defensins, Magainins, Protegrins
- Complement System
- Fever
- 1ST LINE OF DEFENCE (PHYSICAL BARRIERS)
- Antibacterial defense eg. SALIVA and TEARS
- Prevents entry eg. SKIN
- Traps dirt and microbes eg. MUCUS LININGS
- Low pH killls eg. STOMACH ACID
- Antibacterial defense eg. SALIVA and TEARS
- 2ND LINE OF DEFENCE (PHYSIOLOGICAL BARRIERS)
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