The Immune System

Beschreibung

- Structure and mode of action of phagocytes - B and T lymphocytes - Structure and Function of Antibodies
Dean Lundie
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Dean Lundie
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Zusammenfassung der Ressource

The Immune System
  1. 1) Phagocytes
    1. 1) Phagocyte recognises the antigens on a pathogen
      1. 2) Cytoplasm of phagocyte engulfs pathogen
        1. Opsonins help as they are molecules in the blood that attach to foreign antigens
        2. 3) The pathogen is now contained in a phagosome in the cytoplasm of the phagocyte
          1. 4) A lysosome fuses with the phagosome. The enzymes break the pathogen down
            1. 5) The phagocyte then presents the pathogens antigens. It is now an antigen presenting cell
            2. 2) T Lymphocytes
              1. Type of White Blood Cell
                1. Surface is covered with receptors
                  1. 1) Receptors bind to antigens on Antigen-presenting cells
                    1. 2) Each T Lymphocyte has a different receptor
                      1. 3) When the receptor meets a complimentary antigen, it binds to it. This means each lymphocyte is unique
                        1. 4) This activates the T Lymphocyte
                          1. Clonal Selection
                          2. 5) They then divide to produce clones. Different types of Lymphocyte have different functions
                            1. Clonal Expansion
                              1. T Helper
                                1. Release substances to help activate B Lymphocytes and killer cells
                                2. T Killer
                                  1. Kill cells with a virus
                                  2. T Regulatory
                                    1. Suppress immune response
                                3. 3) B Lymphocytes
                                  1. Type of White Blood Cell
                                    1. Covered with Antibodies
                                      1. 1) Antibodies bind to Antigens
                                        1. 2) Each Antibody has a different shape
                                          1. Unique complimentary antigen-antibody complex
                                          2. 3) This activate the B Lymphocyte
                                            1. Clonal Selection
                                            2. 4) Divide by mitosis into plasma and memory cells
                                              1. Clonal Expansion
                                            3. 4) Plasma cells and Antibodies
                                              1. 1) Plasma cells are clones of B Lymphocytes
                                                1. 2) They secrete loads of antibodies specific to the antigen
                                                  1. 3) They will bind to the antigen and form complexes
                                                    1. Antigen-Antibody Complex
                                                      1. Variable region is the binding site
                                                        1. Hinge region allows flexibility for binding
                                                          1. Constant region allows binding to receptors on immune system cells
                                                            1. Disulfide bridges hold polypeptide chains together
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