Coronary Heart Disease

Anmerkungen:

• Coronary arteries become clogged with plaques.

1. Patho
   1. Arteriosclerosis

      Anmerkungen:

      • Hardening of the arteries. Walls become thick and stiff, lose their elasticity and become calcified. They can no longer VD and therefore can't respond to changes in BP.
   2. Atherosclerosis

      Anmerkungen:

      • 1. Damage to the tunica intima 2. Fatty streak formation 3. Fibrous plaque 4. Unstable plaque
      1. Consequences of an atheroma

         Anmerkungen:

         • Obstructs lumen - impairing blood flow Impaired blood flow - thrombus formation Plaque rupture - thrombus formation.
2. Risk factors

   Anmerkungen:

   • Type 2 diabetes Hypothyroidism High diet sat fat (high LDLs) HTN - shearing forces           - afterload, increased O2 demand Obesity Smoking Sedentary lifestyles Alcohol
3. Problems on exertion

   Anmerkungen:

   • On exertion the demand of the heart increases meaning the myocardium has to contract quicker and more forcefully. This demand is only met by increasing BP, however the heart doesn't have enough O2 and nutrients to cope with the demand and the heart becomes ischaemic.
4. Occlusion %s

   Anmerkungen:

   • At rest - 75% occlusion of at least one point of the arterial system leads to ischaemia. On exercise - 50% occlusion of at least one point of the arterial system leads to ischaemia.
5. Clinical manifestations of ischaemia

   Anmerkungen:

   • 1. Angina 2. Myocardial Infarction.
6. Angina pectoris

   Anmerkungen:

   • 98% due to atheroma 2% due to extreme vasospasm or hypotension. A discomfort in the chest and surrounding areas due to a transiently inadequate blood supply to the myocardium
   1. Types
      1. Stable

         Anmerkungen:

         • A reproducible pattern of intensity and duration.
      2. Unstable

         Anmerkungen:

         • A changeable pattern of pain that may occur at rest. It is more serious than stable angina.
   2. Clinical markers
      1. Location

         Anmerkungen:

         • Behind upper/middle 2/3 of sternum      +/- lower sternum May extend to chest, neck, lower jawRadiating down arms to fingers
      2. Character
      3. Relation to exercise/stress

         Anmerkungen:

         • Stable - comes on with exertion and is relieved by rest. Unstable - may be present at rest 
      4. Duration of the attack

         Anmerkungen:

         • Usually lasts for 1-5mins but can last for 15-20mins. S + S:  - SOB - faintness - anxiety The longer the pain lasts the higher the risk of infarction.
   3. ECG

      Anmerkungen:

      • shows flattened/depressed ST segment - suggestive of ischaemia - more than 0.5mm indicates ischaemia.
   4. Diagnosis
   5. Prognosis

      Anmerkungen:

      • 35% live for 10 years +
   6. Treatment
      1. General management

         Anmerkungen:

         • - Decrease the risk factors e.g. stop smoking, diet and exercise - Increase aerobic fitness - Avoid intense cold, walking in the wind etc as this will cause VC - affecting afterload so heart has to work harder. - Regular assessment of blood lipid profiles
      2. Pharmacological management
         1. Nitrates

            Anmerkungen:

            • GTN immediately relieves angina pain by promoting rapid VD of coronary arteries, and therefore increasing blood flow and O2 delivery to the myocardium. Side effects: CAUSES HYPOTENSION AND SYNCOPE. - causes widespread VC in arterioles and veins. Both decreasing BP. Hypotension can cause fainting, dizziness and headaches as a result of decreased cerebral perfusion. 
         2. Beta blockers

            Anmerkungen:

            • Block the action of the SNS. Therefore limiting HR max and cardiac contractility. They are cardio-protective as they limit the work of the heart, reducing its demand for O2 and reduces the chances of it becoming ischaemic. Side effects: Fainting Fatigue Dizziness NB. 1. They can block the action of the SNS on brochioles (therefore poor oxygen exchange) 2. May not be able to take if on beta2 agonists for pts with bronchial hyper-responsiveness (e.g. asthma or COPD) 3. lower HRmax during cardiac rehab = 220-age-30bpm.
         3. Ca2+ antagonists

            Anmerkungen:

            • Cardio-protective Limit contractility and promote coronary artery VD which increases blood flow to the myocardium and causes peripheral VD. Increased peripheral VD lowers TPR and BP, reducing the work of the heart. Side effects: - dizziness - fainting - headaches
         4. Statins

            Anmerkungen:

            • Reduces the rate of LDL:HDL, reducing the likelihood of further atheroma formation. Side effects: - muscle cramps - headaches - heart burn
      3. Surgical management
         1. PTCA

            Anmerkungen:

            • Percutaneous transluminal coronary angiplasty - inflation of a balloon to compress the fatty tissue in the artery and increase lumen size, therefore improving blood flow.
         2. Stent

            Anmerkungen:

            • Metal coil to hold the artery open. Need to take aspirin to prevent clot formation.
         3. CABG
   7. What to do in the event of an attack?

      Anmerkungen:

      • - stop and rest - seat upright - give GTN - check pulse and respiration - is O2 required - 3 doses of GTN in 10 mins if no relief then treat as a heart attack. - Don't want to lie them down because it displaces blood, increasing VR, increasing the work of the heart, making it more likely to be ischaemic. MUST BRING NITRATES WITH THEM!
7. Myocardial infarction

   Anmerkungen:

   • myocardial necrosis secondary to an acute and irreversible interruption of coronary blood supply. The fibrous cap on the atheroma has split, triggering a platelet response and thrombus formation. Occluding the artery. Tissue doesn't cope well with prolonged ischaemia.
   1. Clinical features

      Anmerkungen:

      • Pain, similar to angina in distribution and type. Duration 20-30mins  Not associated with exertion and not relieved by GTN.
      1. Common symptoms

         Anmerkungen:

         • Breathlessness Dizziness Hypotension Rapid pulse Cold and clammy peripheries Distress, anxiety and fear.
   2. Pathology

      Anmerkungen:

      • Central zone - irreversible damage. Peripheral zone - can be salvaged providing it is repurfused quickly. This limits myocardial dysfunction.
   3. Reperfusion

      Anmerkungen:

      • Achieved by  - Thromboembolytics causing fibrinolysis. Has to be given within the hour. - PTCA - ballooning +/- stent - CABG
   4. What happens to the dead tissue?

      Anmerkungen:

      • Macrophages engulf the debris 2/52 Scar tissue replaces necrotic myocardium 2-8/52 Scar tissue (collagen fibres) is non contractile and can't conduct electrical impulses so leads to some dysfunction of the heart.
   5. Diagnosis

      Anmerkungen:

      • ECG - look for ST elevation STEMI Clinical presentation Biomechanical markers - the greater the enzyme release the greater the size of the infarction.
   6. Prognosis

      Anmerkungen:

      • Depends on: - extent of the infarction - extent of collateral channels - location of infarct - PMH - is the myocardium already compromised?
   7. Treatment

      Anmerkungen:

      • Ensure viable SaO2 levels - give O2 Pain relief - give morphine Rapid dissolution of an occluding thrombus - Thromboembolytics Prevention of post MI coagulaton e.g. intramural thrombus formation - Anticoagulants Long term prevention of thrombus formation - aspirin.
      1. Thromboembolytics

         Anmerkungen:

         • Within 1 hr.  Vital for reperfusion. Breaks down the thrombus, salvaging as many myocytes as possible, limiting size of infarct
      2. Anticoagulants

         Anmerkungen:

         • To prevent progression or occurrence of a thrombus in the coronary arteries or the left side of the heart (mural thrombus). Also prevents DVTs/PEs that may occur post-op.
      3. Aspirin

         Anmerkungen:

         • Long-term anti-platelet therapy. Low dose aspirin 75mg a day to reduce platelet adhesion and therefore reducing thrombus formation.
      4. Surgery

         Anmerkungen:

         • Emergency balloon angioplasty or CABG where reperfusion is unsuccessful. May need to repair any secondary damage e.g. to valves or septum. Pt must be stable for surgery.
      5. Physio

         Anmerkungen:

         • Early mob - anti-PE stategy Progressive exs Increase confidence/empowerment Prevent deconditioning Life-style education Home exs Cardiac rehab
      6. Ongoing pharmacology

         Anmerkungen:

         • Aspirin ACE inhibtors Beta blockers Anti-arrythmics Statins
   8. TIME WASTED = MUSCLE WASTED
   9. Complications

      Anmerkungen:

      • SEE WORKBOOK! Cardiogenic shock LVF or RVF PEs CVA Post infarct angina Shoulder-hand syndrome