Zusammenfassung der Ressource
Cisplatin
- Platinol-AQ & Platinol (Brand Names)
- Cancers Treated
- Metastatic Testicular Tumors
- Metastatic Ovarian Tumors
- Advanced Bladder Cancer
- First-Line
Treatment of
Ovarian
Cancer
- Unlabeled Uses
- Non-Small-Cell
Lung Cancer
- Brain Cancer
- Adrenal Cortex Cancer
- Breast Cancer
- Cervix Cancer
- Uterine Cancer
- Endometrium Cancer
- Head and Neck Cancer
- Esophogeal Cancer
- Lung Cancer
- Liver Cancer
- Osteogenic Sarcomas
- Numerous Other Malignancies
- Drug Classification
- Platinum Based Antineoplastic
- Drug Reconstitution & Dilution
- Comes in a liquid
form so no
reconstitution is
required
- Combined with
Mannitol in either
NS or D5 1/2 NS 1/2.
D5W alone cannot
be used.
- Physiological Concepts
- Evidence of Tumors
- Symptoms will vary
depending on the type
of cancer
- Non-Drug Treatments or
Lifestyle Modifications
- Use of essential oils
- Super Foods
- Nutrients, Foods &
Products that help to
build up the immune
system
- Get plenty of rest
- Exercise
- Get to and maintain a healthy weight
- Routes of
Administrtion
- Can be used in all populations.
Pediatric patients need close
monitoring and testing. IV USE
ONLY!!
- Usual Dose & Rate of
Administration
- Dose & Rate will Vary based on
patient. Dosed using BSA. Not
to be run as a rapid infusion.
Typically run over 2 hours
- Contraindications &
Warnings
- Hypersensitivity to
cisplatin or other
platinum-containing
compounds.
- Myelosuppressed
Patients
- Patients with
pre-existing impaired
renal function
- Patients with a hearing
deficit
- Pregnancy Risk
Category D
- Antidote for Patient
Reaction
- There is no specific antidote available
- Discontinue Use
- Administration of whole blood products
- Drug Drug Interactions
- Aminoglycosides (i.e. Gentamicin)
- Loop Diuretics (i.e furosemide)
- Anticonvulsant Agents
- Ohter Antineoplastic agents
- Live Virus Vaccines
- Drug Food
Interactions
- None
- Ongoing Monitoring
- Side effects should be monitored
closely as they can be frequent and
become more severe with every dose
after the fist.
- Hearing tests are ordered
for high dose therapies
- Blood Tests such as a CBC
will be done to monitor
electrolytes and organ
functions
- Interesting Fact: First
platinum-containing
anti-cancer drug