7291473
Beschreibung
Mindmap von hassan mohammed, aktualisiert more than 1 year ago
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Erstellt von hassan mohammed
vor mehr als 7 Jahre
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Yasser is falling
behind
- Macro-anatomy of pituitary gland
- location
- sella turcica (hypophyseal fossa) cavity within
body of sphenoid bone housing pituitary gland,
capsule of the gland is adherent to dura mater
- diaphragma sellae : fold of dura mater cover the
superior aspect of pituitary, Extend b/t ant. & post
clinoid processes,Forming roof to sella turcica
- infundibulum pierces the diaphragma
sellae, connect the pituitary to the
hypothalamus
- sella turcica (hypophyseal fossa) cavity within
body of sphenoid bone housing pituitary gland,
capsule of the gland is adherent to dura mater
- Lobes
- Adenohypophysis (75% of
total wt.) anterior lobe
- Vascular
connection
- parts
- pars distalis
- Pars intermedia
- Pars tuberalis.
- pars distalis
- supplied by superior
hypophysial
artery
- Vascular
connection
- Neurohypophysis (posterior lobe)
- neuronal connection
- is directly connected to
Supraoptic paraventricular
nuclei of the hypothalamus
- supplied by inferior
hypophysial artery
- parts
- Pars nervosa
- Median eminence
- Infundibulum
- Pars nervosa
- neuronal connection
- Adenohypophysis (75% of
total wt.) anterior lobe
- location
- Histological Structure
of Pituitary Gland
- Neurohypophysis
- Unmyelinated nerve fibers
- pituicyte
- capillaries
- Unmyelinated nerve fibers
- Adenohypophysis
- cells of pars distalis
- Chromophobes
- Chromophils
- Acidophils
- somatotrophs
- mammotrophs
- somatotrophs
- Basophils
- gonadotrophs
- thyrotrophs
- corticotrophs
- gonadotrophs
- Acidophils
- Chromophobes
- cells of Pars Intermedia
- Basophil cells secrete
MSH (melanocyte
stimulating hormone).
- Basophil cells secrete
MSH (melanocyte
stimulating hormone).
- Cells of Pars
tuberalis
- Cuboidal cells with
Basophilic granules.
- Cuboidal cells with
Basophilic granules.
- cells of pars distalis
- Neurohypophysis
- PATHOLOGY OF
PITUITARY GLAND
- Hypopituitarism
- Causes
- PITUITARY TUMORS
- Ischæmic necrosis of the pituitary gland
- PITUITARY APOPLEXY
- IATROGENIC HYPOPITUITARISM
- TRAUMA + INFILTRATIVE DISEASES
- PITUITARY TUMORS
- pharmacological treatment
1-Somatropin 2-Mecasermin
..etc
- Causes
- Hyperpituitarism
- The most common cause of hyperpituitarism is an
adenoma arising in the anterior lobe. Other, less
common causes include hyperplasia and carcinomas
of the anterior pituitary
- pharmacological treatment : 1. somatostatin receptor
agonists (also known as somatostatin receptor ligands
[SRLs] or somatostatin analogues), 2. dopamine
analogues 3. GH receptor antagonists
- The most common cause of hyperpituitarism is an
adenoma arising in the anterior lobe. Other, less
common causes include hyperplasia and carcinomas
of the anterior pituitary
- Pituitary Adenomas
- Pituitary adenomas are benign neoplasms of the
anterior lobe of the pituitary and are often associated
with excess secretion of pituitary hormones treated
by surgical resection, medical therapy, and radiation
therapy.
- Pituitary adenomas are benign neoplasms of the
anterior lobe of the pituitary and are often associated
with excess secretion of pituitary hormones treated
by surgical resection, medical therapy, and radiation
therapy.
- Hypopituitarism
- physiology of hormones
- 1-Amines: catecholamine,
etc
2--Peptides/polypeptides:
insulin,etc
- GROWTH HORMONE
- ACTIONS
- 1-The most dramatic effect of GH is stimulation of
postnatal linear growth. 2- Local production of IGF-1
3-GH stimulates lipolysis ,GH increases
gluconeogenesis ,GH increases protein synthesis in
muscle.etc.
- 1-The most dramatic effect of GH is stimulation of
postnatal linear growth. 2- Local production of IGF-1
3-GH stimulates lipolysis ,GH increases
gluconeogenesis ,GH increases protein synthesis in
muscle.etc.
- Control of GH Secretion
- Hypoglycemia ,Hyperglycemia
,exercise,Somatostatin Sex
steroids ,sleep
- Hypoglycemia ,Hyperglycemia
,exercise,Somatostatin Sex
steroids ,sleep
- Assessment of GH
- 1-Insulin Stress Test. 2-Glucose
Tolerance Test. 3-Measurement
of IGF-1 to assess GH excess (not
confirmative).
- 1-Insulin Stress Test. 2-Glucose
Tolerance Test. 3-Measurement
of IGF-1 to assess GH excess (not
confirmative).
- ACTIONS
- Water-soluble ,Short half-life (minutes), Pulsatile
secretion,Act on cell surface receptors Act via
second messenger (cAMP, a rise in intracellular
Calcium, or a receptor tyrosine kinase).
- GROWTH HORMONE
- 3-Steroids: cortisol, etc
- Longer half-life (hours) Act on
intracellular receptors Act on
DNA to alter gene transcription
- Longer half-life (hours) Act on
intracellular receptors Act on
DNA to alter gene transcription
- 1-Amines: catecholamine,
etc
2--Peptides/polypeptides:
insulin,etc
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