Erstellt von Reesha Cornelio
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INNATE IMMUNITY Physical Barrier Stages of infection skin mucous membrane natural flora Natural secretion Adherence of pathogen Penetration of epithilium Local infection of the tissue
ADAPTED IMMUNITY Stages of infection Lymphocytes : Cells with receptors that are highly specific lymphatic spread Adaptive immunity Cell mediated Tcells Humoral Bcells originate in bone marrow but mature in thymus and found tissue and blood Naieve Tcell CD4+ CD8 cells origniate and develop in the bone marrow Naieve Bcell Plasma Cells Memory Cells Antibodies Structure Function diversity Types Neutralisation Oponisation Lysis Antibody dependent cellular toxicity IGM IGG IGA IGD IGE
A body's ability to resist a particular diesase whether natural or as a result of a previous infection
Antigen : molecules recognnised by immune system inducing an immune response. Can be prtoeins , carbohydrates , nucleic scid , lipids or lipopolysacharides
-slow - first line of defence
Activated when the antibody on the B cell recognises an antigen through contact with epitome engulfs it and presents it throgugh an MHC CLASS 2 - helper T cell then comes along rtecognises it and assist B cells to differenciate
Composed to two heavy chains , two domains and two chains. Has a variable domain and constant domain Light chain and heavy chain ' Fc regioin binds to other cell Fab regions binds to antigen
The diversity comes from the splicing that occurs with the genes. Heavy chain is encoded by VDJC and Light chain is encoded by VJC recombination creates unique antibodies per cell Rearrangment VH3DH7JH5 = all matieral b/w v3 to d7 is deleted along with matieral b/w d7 to h5 all the matieral upstream and downstream kept
Variation in heavy chain constant regioin detemines isotype Intially make IgM in naieve cells but then upon maturation make isotypes throgyuh class swithching as the variable regions remainsthe same the specifiicity does not chain just the affinity
-expressed in naeive B cells -pentamer -not a high affinity antibody -linked by J chains -very effiecient activating compliment
Major class is serum major class in secodnary response binds receptor exposed by monocytes
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IMMUNITY
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