PHSI3012 02-2 Limitless replicative potential of cancer cells

1

True or false:
Cells which have entered senescence have a large, flattened morphology "like poached eggs".

1

Mutations in p53 and/or Rb can lead to:

1

Cells in "crisis" have which of the following traits?
(select all that apply)

1

The Hayflick limit is:

1

Telomeres shorten by ~( 5 - 15, 50 - 150, 500 - 1,500, 5,000 - 15,000, 130 - 210, 2,000 - 40,000 ) bp with each round of cell division.

3

There are two [main?] telomere maintenance mechanisms. These are Telomerase and ALT.
What does ALT stand for?

1

Which [non-cancerous] cell type does NOT have shortening telomeres during replication?

1

Telomerase is:

1

Which telomere maintenance mechanism is used in the majority of cancers?

3

Telomerase can be detected using which of the following methods:
(select all that apply)

3

ALT can be detected using which of the following methods?
(select all that apply)

PHSI3012 02-2 Limitless replicative potential of cancer cells Content: * Hallmarks of Cancer * Cellular proliferation * Mortality vs immortality * Telomeres * Telomerase * ALT

PHSI3012 02-2 Limitless replicative potential of cancer cells

PHSI3012 02-2 Limitless replicative potential of cancer cells

True or false: Cells which have entered senescence have a large, flattened morphology "like poached eggs".

Mutations in p53 and/or Rb can lead to:

Cells in "crisis" have which of the following traits? (select all that apply)

The Hayflick limit is:

Telomeres shorten by ~5 - 15 50 - 150 500 - 1,500 5,000 - 15,000 130 - 210 2,000 - 40,000( 5 - 15, 50 - 150, 500 - 1,500, 5,000 - 15,000, 130 - 210, 2,000 - 40,000 ) bp with each round of cell division.

There are two [main?] telomere maintenance mechanisms. These are Telomerase and ALT. What does ALT stand for?

Which [non-cancerous] cell type does NOT have shortening telomeres during replication?

Telomerase is:

Which telomere maintenance mechanism is used in the majority of cancers?

Telomerase can be detected using which of the following methods: (select all that apply)

ALT can be detected using which of the following methods? (select all that apply)

True or false:
Cells which have entered senescence have a large, flattened morphology "like poached eggs".

Cells in "crisis" have which of the following traits?
(select all that apply)

Telomeres shorten by ~( 5 - 15, 50 - 150, 500 - 1,500, 5,000 - 15,000, 130 - 210, 2,000 - 40,000 ) bp with each round of cell division.

There are two [main?] telomere maintenance mechanisms. These are Telomerase and ALT.
What does ALT stand for?

Telomerase can be detected using which of the following methods:
(select all that apply)

ALT can be detected using which of the following methods?
(select all that apply)