PHSI3011 11-2 Liver in Metabolic Homeostasis

Glucose is taken up in a GLUT2-dependent manner. It’s then stored as Glycogen Glucose 6-Phosphate Pyruvate Glucagon Glycerol( Glycogen, Glucose 6-Phosphate, Pyruvate, Glucagon, Glycerol ) until blood glucose levels drop.

Stages of Lipoprotein and FA uptake:
Stage 1 Stage 2 Stage 3( Stage 1, Stage 2, Stage 3 ) – Hepatic lipase (and Lipoprotein lipase) Periphery Liver( Hepatic lipase (and Lipoprotein lipase), Periphery, Liver ) resides on endothelial cells to hydrolyse VLDL-TAG to FAs for uptake

Stages of Lipoprotein and FA uptake:
Stage 1 Stage 2 Stage 3( Stage 1, Stage 2, Stage 3 ) – Hepatic lipase (and Lipoprotein lipase) Periphery Liver( Hepatic lipase (and Lipoprotein lipase), Periphery, Liver ): TAG-rich VLDL interacts with VLDL-R, enters lysosomal pathway for hydrolysis and TAG synthesis.

Stages of Lipoprotein and FA uptake:
Stage 1 Stage 2 Stage 3( Stage 1, Stage 2, Stage 3 ) – Hepatic lipase (and Lipoprotein lipase) Periphery Liver( Hepatic lipase (and Lipoprotein lipase), Periphery, Liver ): VLDL-remnants interact with a range of receptors for endocytosis.

Loss of CD36 in the liver leads to Increased Unaffected Reduced( Increased, Unaffected, Reduced ) Plasma FA levels. Plasma FAs Inhibit Stimulate( Inhibit, Stimulate ) LPL activity. Therefore loss of CD36 Reduces Increases( Reduces, Increases ) Chylomicron/VLDL-TAG hydrolysis (breakdown). …Leading to Accumulation Shortage( Accumulation, Shortage ) of TAG in the circulation.