PHSI3011 05-2 Maintenance of Bone Health

1

If Resorption < Formation:

1

Which of the following are bone mass determinants:

1

Sclerostin is released by which of the following?

1

Sclerostin __________ Wnt signalling in Osteoblasts/Osteocytes

1

With deformity of bone (on loading), sclerostin secretion:

1

SOST = ??

1

Obligatory urine Calcium loss is ( 150-200, 1000, 25, 300 ) mg/d (although ( More, Less ) after menopause).

1

Recommended daily allowance for calcium changes according to age, but broadly mostly around:

1

Vitamin D ( Decreases, Increases ) gut Calcium absorption:

1

A non-Calcium-rich diet will usually have approximately ❌ mg/d Calcium. This is ❌% of recommended intake.

300

1000

150-200

30

15-20

25

100

70

1

True or false: Exposure to the sun is [normally] our main source of Vitamin D.

1

True or false: Diet is [normally] our main source of Vitamin D.

1

What’s the recommended daily intake of Vitamin D?

1

Which of the following accelerates Vitamin D degradation?

2

Which of the following groups are commonly associated with increased risk of Vitamin D deficiency?

1

In a study of 100 office workers in Sydney, sunscreen users had ( Higher, Lower ) Vitamin D levels compared to non-users.

1

How does Vitamin D help bone health?

1

Vitamin D deficiency leads to increased bone turnover. Severe Vitamin D deficiency leads [primarily] to?

1

Adequate levels of ( 25OHD, 25HD, 25OD, 2OH5D, 20O5HD ) are needed to maximise Calcium absorption and ( Suppress, Increase ) ParaThyroid Hormone (PTH).

1

25OHD = ??

1

Severe CALCIUM deficiency can lead to:

1

Severe VITAMIN D deficiency can lead to Osteomalacia/Rickets. Are they the same thing?

1

Which of the following helps to maintain normal balance between bone formation and resorption:

1

True or False: Oestrogens help to keep bone cells alive.

1

True or False: Androgens help to keep bone cells alive.

1

True or false: Anorexia leads to weak bones solely through nutrient deficiency.

1

Glucocorticoids (Cortisone etc) are catabolic at pharmacologic doses. Where does each manifestation occur?
↓ Calcium absorption in the ❌;
↑ Calcium losses in the ❌;
↓ IGF-1 in the ❌;

Gut

Kidney

Bone

1

Protein intake helps:

1

If a diet contains inadequate Calcium to replace urinary losses, what happens?

PHSI3011 05-2 Maintenance of Bone Health

PHSI3011 05-2 Maintenance of Bone Health

If Resorption < Formation:

Which of the following are bone mass determinants:

Sclerostin is released by which of the following?

Sclerostin __________ Wnt signalling in Osteoblasts/Osteocytes

With deformity of bone (on loading), sclerostin secretion:

SOST = ??

Obligatory urine Calcium loss is 150-200 1000 25 300( 150-200, 1000, 25, 300 ) mg/d (although More Less( More, Less ) after menopause).

Recommended daily allowance for calcium changes according to age, but broadly mostly around:

Vitamin D Decreases Increases( Decreases, Increases ) gut Calcium absorption:

A non-Calcium-rich diet will usually have approximately ❌ mg/d Calcium. This is ❌% of recommended intake.

True or false: Exposure to the sun is [normally] our main source of Vitamin D.

True or false: Diet is [normally] our main source of Vitamin D.

What’s the recommended daily intake of Vitamin D?

Which of the following accelerates Vitamin D degradation?

Which of the following groups are commonly associated with increased risk of Vitamin D deficiency?

In a study of 100 office workers in Sydney, sunscreen users had Higher Lower( Higher, Lower ) Vitamin D levels compared to non-users.

How does Vitamin D help bone health?

Vitamin D deficiency leads to increased bone turnover. Severe Vitamin D deficiency leads [primarily] to?

Adequate levels of 25OHD 25HD 25OD 2OH5D 20O5HD( 25OHD, 25HD, 25OD, 2OH5D, 20O5HD ) are needed to maximise Calcium absorption and Suppress Increase( Suppress, Increase ) ParaThyroid Hormone (PTH).

25OHD = ??

Obligatory urine Calcium loss is ( 150-200, 1000, 25, 300 ) mg/d (although ( More, Less ) after menopause).

Vitamin D ( Decreases, Increases ) gut Calcium absorption:

In a study of 100 office workers in Sydney, sunscreen users had ( Higher, Lower ) Vitamin D levels compared to non-users.

Adequate levels of ( 25OHD, 25HD, 25OD, 2OH5D, 20O5HD ) are needed to maximise Calcium absorption and ( Suppress, Increase ) ParaThyroid Hormone (PTH).

Glucocorticoids (Cortisone etc) are catabolic at pharmacologic doses. Where does each manifestation occur?
↓ Calcium absorption in the ❌;
↑ Calcium losses in the ❌;
↓ IGF-1 in the ❌;