PHSI3012 11-2 Insulin Resistance (T3L4)

1

Which of these effects are where?

Skeletal Muscle

Adipose Tissue

Liver

5

Actions of Insulin. Insulin stimulates and inhibits various things. Which are STIMULATED?

5

Actions of Insulin. Insulin stimulates and inhibits various things. Which are INHIBITED?

2

Definition of Insulin Resistance. There are three of them. Which is which?
“The inability of a known quantity of exogenous or endogenous insulin to increase glucose uptake and utilisation in an individual as much as it does in a normal population.” = the ❌ definition.
“The inability of exogenous insulin to alter post-translational modifications (e.g. phosphorylation) of specific proteins in tissue or cells.” = the ❌ definition.
“The inability of exogenous or endogenous insulin to increase glucose uptake in tissues or cultured cells.” = the ❌ definition.

Clinical

“Sometimes”

Experimental

1

Loss of function of IR in skeletal muscle results in which of the following:

1

Insulin resistance results from a fuck-up in which of the following:

1

Loss of function of Glut4 in Skeletal Muscle results in which of the following:

1

Knockout of the Insulin Receptor in ADIPOSE TISSUE is known as which of the following:

1

True or false: FIRKO results in INCREASED insulin sensitivity in adipose tissue.

1

True or false: FIRKO results in DECREASED insulin sensitivity in adipose tissue.

1

True or false: Knockout of the Insulin Receptor in adipose tissue results in an INCREASE of weight! True? True.

2

Loss of function of Glut4 in ADIPOSE TISSUE results in which of the following:

1

LIRKO results in which of the following:

1

HGP = ??

2

PHSI3012 11-2 Insulin Resistance (T3L4)

PHSI3012 11-2 Insulin Resistance (T3L4)

PHSI3012 11-2 Insulin Resistance (T3L4)

Which of these effects are where?

Actions of Insulin. Insulin stimulates and inhibits various things. Which are STIMULATED?

Actions of Insulin. Insulin stimulates and inhibits various things. Which are INHIBITED?

Loss of function of IR in skeletal muscle results in which of the following:

Insulin resistance results from a fuck-up in which of the following:

Loss of function of Glut4 in Skeletal Muscle results in which of the following:

Knockout of the Insulin Receptor in ADIPOSE TISSUE is known as which of the following:

True or false: FIRKO results in INCREASED insulin sensitivity in adipose tissue.

True or false: FIRKO results in DECREASED insulin sensitivity in adipose tissue.

True or false: Knockout of the Insulin Receptor in adipose tissue results in an INCREASE of weight! True? True.

Loss of function of Glut4 in ADIPOSE TISSUE results in which of the following:

LIRKO results in which of the following:

HGP = ??

“The” Mechanism(s). “The” mechanism of insulin resistance is which of the following:

Insulin resistance is caused by many factors including: