Angina Pharmacotherapy

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Which beta blockers block both beta & alpha receptors?

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Beta‐1, found primarily in ❌, results in increased heart rate, contractility, and atrioventricular (AV) conduction

heart muscle

bronchial & peripheral smooth muscle

adipose

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Beta‐2, found in ❌ smooth muscle; results in vasodilatation and bronchodilation.

bronchial and peripheral vascular

heart muscle

adipose

1

Beta‐3, found in ❌ may reduce cardiac contractility.

adipose tissue and the heart;

heart muscle

bronchial and peripheral vascular smooth

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Beta blockers MOA:

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Which of the following Beta Blockers are eliminated by hepatic metabolism and are lipid soluble

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Why is important to know which BB are eliminated by hepatic metabolism and more lipid soluble?

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Which of the following beta blockers are excreted unchanged by the kidney?

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Metoprolol tartrate is ( shorter‐acting, longer-acting ) and dose ( twice, once ) daily and
Metoprolol succinate ( longer‐ acting, shorter-acting ) and dosed ( once, twice ) daily

1

Atenolol and sotalol are more water soluble and are eliminated unchanged by the kidney. What is the effect of this on plasma half-lives & bioavailability?

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True or False:
BB are first-line therapy to reduce angina episodes & increase exercise tolerance

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BB & CCB are antianginal drugs proven to prevent reinfarction and improve survival in patients who have sustained a MI

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BB should NOT be used in which type of angina patient

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It is important to BB when discontinuing BB therapy

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What are some potential Adverse Effects of Beta Blockers

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T or F
CCB are less effective than BB when treating stable angina

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When are CCB used to treat stable angina?

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What is the caution for using both non‐dihydropyridine and BB?

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CCB improve anginal symptoms by causing coronary and ( peripheral, central ) vasodilatation and ( reducing, increasing ) contractility

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Select the non-dihydropyridine CCB:

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Which types of CCB are preferred for angina

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What is the most concerning adverse effect of dihyrdropyridine (amlodipine, felodipine, nifedipine

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What are potential adverse effects of Dihydropyridines

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What are potential adverse effects of non-dihydropyridines

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What are a prescribers options if a patient gets peripheral edema on a dihydropyridines?

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MOA for nitrate used for stable angina is

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Select the cardioselective beta blockers

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Select the non-cardioselective beta blockers

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Nitrates are used as

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Usually in the form of a sublingual preparation, nitrates onset of action is within ( 2‐5 minutes, 5 - 10 minutes, 1 - 2 minutes ) and duration of action ( 15 ‐ 30 minutes, 5 - 10 minutes, 10 - 20 minutes, 15 - 20 minutes )

1

Select the potential adverse effects of nitrates

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American College of Cardiology/American Heart Association (ACC/AHA) guidelines for calling the emergency services are

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Nitroglycerin tablets are both and sensitive

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Nitroglycerin tablets should be stored in a tightly capped dark bottle in the refrigerator with only a small supply being carried by the patient and discarded after 12 months

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The following are longer-acting nitrate therapies

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How can a patient address the issue of nitrate tolerance with long-term therapies like the transdermal nitroglycerin patch?

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What is a REALLY IMPORTANT nitrate contraindication drug

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Ranolazine is a new drug for stable angina that is recommended for patients that have failed all other antianginal therpies. However, it is contraindicated for the following patients

Quiz am Angina Pharmacotherapy, erstellt von Melanie Grynsztejn am 05/12/2017.

Angina Pharmacotherapy

Angina Pharmacotherapy

Which beta blockers block both beta & alpha receptors?

Beta‐1, found primarily in ❌, results in increased heart rate, contractility, and atrioventricular (AV) conduction

Beta‐2, found in ❌ smooth muscle; results in vasodilatation and bronchodilation.

Beta‐3, found in ❌ may reduce cardiac contractility.

Beta blockers MOA:

Which of the following Beta Blockers are eliminated by hepatic metabolism and are lipid soluble

Why is important to know which BB are eliminated by hepatic metabolism and more lipid soluble?

Which of the following beta blockers are excreted unchanged by the kidney?

Metoprolol tartrate is shorter‐acting longer-acting( shorter‐acting, longer-acting ) and dose *twice* *once*( *twice*, *once* ) daily and Metoprolol succinate longer‐ acting shorter-acting( longer‐ acting, shorter-acting ) and dosed *once* *twice*( *once*, *twice* ) daily

Atenolol and sotalol are more water soluble and are eliminated unchanged by the kidney. What is the effect of this on plasma half-lives & bioavailability?

True or False: BB are first-line therapy to reduce angina episodes & increase exercise tolerance

BB & CCB are antianginal drugs proven to prevent reinfarction and improve survival in patients who have sustained a MI

BB should NOT be used in which type of angina patient

It is important to BB when discontinuing BB therapy

What are some potential Adverse Effects of Beta Blockers

T or F CCB are less effective than BB when treating stable angina

When are CCB used to treat stable angina?

What is the caution for using both non‐dihydropyridine and BB?

CCB improve anginal symptoms by causing coronary and peripheral central( peripheral, central ) vasodilatation and reducing increasing( reducing, increasing ) contractility

Metoprolol tartrate is ( shorter‐acting, longer-acting ) and dose ( twice, once ) daily and
Metoprolol succinate ( longer‐ acting, shorter-acting ) and dosed ( once, twice ) daily

True or False:
BB are first-line therapy to reduce angina episodes & increase exercise tolerance

T or F
CCB are less effective than BB when treating stable angina

CCB improve anginal symptoms by causing coronary and ( peripheral, central ) vasodilatation and ( reducing, increasing ) contractility