Apoptosis = cell death
Necrosis = cell death due to injury
 Energy-dependent
 Only affects necessary cells
 Membrane (bubbles form)
 condenses
 Blebs bud off to break cell up into
 Fragments digested by
 (mitochondrial) pathway: removal of
growth factors/hormones leads to cascade through mitochondrion, eventually producing (protease enzymes) that disintegrate the and cytoskeleton to cause blebbing
 (death-receptor mediated) pathway: death ligand binds to surface receptor to initiate protein cascade that produces caspases
Apoptosis is used in physiological development and ; if cells ordinarily divide, old ones may need to be destroyed