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Physical methods for microbial growth control
Chemical methods for microbial growth control
sterilization
disinfection
antiseptis
sanitation
autoclave
Pasteurization
Flash Pasteurization
Ultra-high temperature Pasteurization (UHT)
What reduces the effectiveness of disinfectants/antiseptics?
Antimicrobial drugs/Antibiotics
bacteriostatic growth
bactericidal growth
bacteriolytic growth
Minimal Inhibitory Concentration (MIC)
Streptomyces antibiotic production
spectrum of action
Mechanism of Action (MOA)
Examples of drugs that target well studied areas
Target: cell wall biosynthesis
how B-lactam ring binds to PBP
different steps of cell wall biosynthesis to be blocked
target: DNA supercoiling/replication/integrity
DNA gyrase
target: Metabolism
folic acid and PABA
target: protein synthesis
Napthacene ring system and protein synthesis
all steps of protein synthesis and corresponding drugs
antibiotic resistance mechanisms
Triclosan
Triclosan resistance: experimental methods
results of Triclosan experiments
Problems with Triclosan today
Triclosan effect on efflux pumps
