Ch 5 (Absorption and Distribution of Toxicants.

Summary Diagram of the disposition of toxicants.

What is the relationship between exposure and absorption

Toxicological response is related to

What is the major physical barrier?

Name different routes of administration

Steps Post Absorption

Pharamaco-Toxicokinetics

Pharamaco-Toxicodynamics

Toxicant passage through membranes to the site of action.

Lipid bilayer mechanisms of transport

Name some features of Passive diffusion

Diffusion coefficient primarily depends on

Partition Coefficient primarily depends on

(Ch-Cl)

What physiochemical characteristics determine routes and rate of absorption.

What is bioavailability?

The most efficient route of drug entry or delivery

Gi tract diagram pH

GI tract Functions.

Function of epithelial cells

Arterioles

Venules

Small Intestine Structure

First pass effect Diagram

First pass effect definition

Pathway of dermal absorption

Epidermal Layer

Particle Sizes and Deposition

Lung Deposition Mechanism

Factors to consider in respiration injury from gases and vapor

Gases and vapor with low water solubility

Gases and vapor with high water solubility