Genetics and Evolution VI

Name 4 types of mutations

What are transition mutations?

What are transition mutations?

Name 5 causes for spontaneous substitutions

What is depurination?

How to get uracil from deamination

Thymine

What do these deamination events generate?

What sort of mutations are common in species with heavily methylated cytosine?

Name 2 examples of chemical mutagens

Name an example of an alkylating agent and its effect. (4)

What are base analogues? Name an example.

What are the forms of 5-bromouracil and what do they resemble?

What does this cause?

Name 3 different types of mutations that affect protein function

What's the effect of a silent mutation?

What's the effect of a missense mutation?

What's the effect of a Nonsense mutation?

What are the potential consequence of single base pair changes?

Why is it unlikely for a SBP change to be serious?

Why isn't this true for E.Coli?

What can cause INDELs?

What do DNA intercalating agents cause?

What are DNA intercalating agents?

Name an example of a DNA intercalating agent

What is replication slippage?

What is Huntington's caused by?

What are the effects of small INDELs within the coding strand? (3)

What are the effects of small INDELs outside of a coding strand?