Cell Signalling I

Intercellular communcation

Paracrine

Autocrine

Endocrine

Juxtacrine

Cell influence response

Cell signalling for cell surface R's (9)

Modification of proteins for signal transduction

How is this tightly regulated?

Termination of Signal (3)

Eliminate EC ligand

Deactivate signal transduction proteins

Remove +R from PCM via Endocytosis

Natural endogenous kinases (3)

Epinephrine/histamine are

Prostaglandins are

Glucagon and insulin are

Hormones detected by IC R

Cytokines are

3 Examples
IITNF

What's their function

Growth factors are

What type of signalling do they employ?

What's their function?

Agonist

Antagonists

Degrees of agonist action

Factors of drug action (2)

What is affinity?

What is their intrinsic action?

What does a value of 1 mean?