Erstellt von Zena Dodds
vor mehr als 6 Jahre
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what is metabolism and pharmokinetics
What does ADME stand for? +2 bonus
defiintion of each ADME?
PT1 ADM
defintion of ADME?
PT2 E +2bonus
what is the main goal of DMPK
Whats the difference between in VITRO and in VIVO
what are 8 industry standard in vitro DMPK areas to assay
what are the measured physiochemcal properties
What is checked for in chemical stability assays
what is checked for in permeability
whats checked for in metabolism assays
what is checked ofr in cDDI and bioactivation risk assays
whats protein binding assays looking for
and whats PgP looking for
difference between doses in vitro and in vivo?
what are the results from:
1)poor absorption or extenisive first pass metabolism
2)inappropriate distribution
3)large dist. vol/ tissue uptake
4) high protein binding
5) rapid systemic clearance
what is an ideal drug
What should a target product profile include?
what are 3 structural features that determines its physical props
what will increasing charge, ionisation or hydrogen bonding capacity do to a molecule?
what will increasing lipophilicity do ?
effects of increasing lipophilicity
what is renal clearance important for
if logD7.4 is greater than 0 what is the renal clearance
if LogD7.4 is less than 0 what is the renal clearance
what are lipinskis rules
for monikas rules whats the acceptable rotatable bonds and
what is the general guide for lipophilicity when Log D7.4 is <1
what is the general guide for lipophilicity when Log D7.4 is between 1 and 3
what is the general guide for lipophilicity when Log D7.4 is between 3 and 5
what is the general guide for lipophilicity when Log D7.4 is >5
what kind of drugs will passively cross a membrane?
how do molecules diffuse through a lipid membrane
what is polar surface area defined as
Solubility is a determinant of
how can solubility be increased
name 5 things that low solubility can result in
what is kinetic solubility
name 4 kinetic solubility advantages
how is a kinetic solubility tested
name an advantage and 3 disadvanatges to kinetic aqueous solubility using laser nephelometry
name 7 strategies to increase solubility
8 strategies to improve permeability