GEGE2001 Week 03 (L05 & L06)

Frage 1 von 15

2

(from end of L05 slides)
In a particular cell, a non Watson-Crick base pair (T-G) is formed during DNA replication. What is likely to happen next?

Wähle eine der folgenden:

Polymerase *probs* removes it, often via 3' exonuclease activity
Polymerase *probs* removes it, often via 5' exonuclease activity
Polymerase *probs* removes it, often via 3' endonuclease activity
Polymerase *probs* removes it, often via 5' endonuclease activity

Erklärung

Frage 2 von 15

2

(from end of L05 slides)
How does a frameshift mutation differ from a missense mutation?

Wähle eine der folgenden:

Missense affects many codons; Frameshift mutation does not.
Frameshift affects many codons; Missense mutation does not.
Frameshift affects many codons; Missense mutation only affects 3.
Missense affects many codons; Frameshift mutation only affects 3.

Erklärung

Frage 3 von 15

2

(from end of L05 slides)
Did the fluctuation test show that bacterial cells induce mutation upon exposure to the selective agent (viral infection)? Explain. (well, don’t explain here, but be ready to)

Wähle eine der folgenden:

No.
Yes.

Erklärung

Frage 4 von 15

1

DNA is replicated in:

Wähle eine der folgenden:

S phase
M phase
G phase
Cytokinesis
Telekinesis

Erklärung

Frage 5 von 15

2

UV:

Wähle eine oder mehr der folgenden:

light has HIGH energy
light has LOW energy
damage forms a join between two adjacent bases, usually Thymine (forming a Thymine dimer)
damage forms a join between two adjacent bases, usually Cytosine (forming a Cytosine dimer)
damage forms a join between two adjacent bases, usually Adenosine (forming a Adenosine dimer)
damage forms a join between two adjacent bases, usually Guanine (forming a Guanine dimer)
damage forms a join between two adjacent bases, usually Adenine (forming a Adenine dimer)

Erklärung

Frage 6 von 15

1

Which of the following is NOT a type of DNA mutation (necessarily)?

Wähle eine oder mehr der folgenden:

Indels
Incels
Transitions
Transversions

Erklärung

Frage 7 von 15

2

Types of mutations AT THE PROTEIN-CODING LEVEL. Fill in the blanks:
Silent mutation: ❌;
Missense mutation: ❌;
Nonsense mutation: ❌;
Frameshift ❌.

Klicke und ziehe, um den Text zu vervollständigen.

bp change, NO amino acid sequence change

bp change, amino acid change

bp change, early stop codon

1bp+ indel, alters reading frame

Erklärung

Frage 8 von 15

1

UV repair in humans is through:

Wähle eine oder mehr der folgenden:

Nucleotide excision repair
Enzyme photolyase

Erklärung

Frage 9 von 15

1

A mutation resulting in COPY NUMBER VARIATION can vary between identical twins. Therefore it happens during:

Wähle eine der folgenden:

Mitosis
Meiosis
Both of the above
None of the above

Erklärung

Frage 10 von 15

1

What does the image above show?

Wähle eine oder mehr der folgenden:

Gene expression of different members of a gene family varying in different parts of the same plant
Gene expression of different members of a gene family varying in different stages of the same plant's development

Erklärung

Frage 11 von 15

2

(from end of L06 slides)
Variation in gene regulation = mutations that alter the amount of protein product, without a chance in the amino acid sequence. Basically a regulatory mutation. This can be in which of the following:

Wähle eine oder mehr der folgenden:

promoters
introns
5’-UTR
3’-UTR
exons
5’-URT
3’-URT

Erklärung

Frage 12 von 15

1

Blonde vs brown-hair is an example of variation in:

Wähle eine der folgenden:

gene expression
aa sequence
gene splicing

Erklärung

Frage 13 von 15

2

(from end of L06 slides)
Define a gene family:

Wähle eine der folgenden:

A set of several similar genes, formed by duplication of a single original gene
A set of several copies of identical genes, responsible for varying levels of a single trait

Erklärung

Frage 14 von 15

1

(from end of L06 slides)
What is a pseudogene?

Wähle eine oder mehr der folgenden:

A non-functional copy of a gene including a regulatory mutation that prevents its expression
A non-functional copy of a gene including a premature stop codon within the gene that prevents its expression

Erklärung

Frage 15 von 15

2

(from end of L06 slides)
What are the 2 most likely sources of phenotypic and genomic variation between individuals within a species? (…excluding environmental factors for some reason)

Wähle eine oder mehr der folgenden:

Variation in amino acid sequences
Regulatory sequences
Variation in gene number
Variation in splicing
Novel genes

	Erstellt von Michael Jardine vor etwa 6 Jahre

L05 - Mutation and repair: - Errors and repair; - Types of mutations; - Consequences of mutation L06 - Mutation and phenotypic variation: - Phenotypic differences can be obtained by: * Adding sequences to the genome; * Changing sequences or gene expression; * Changing the environment

GEGE2001 Week 03 (L05 & L06)

Frage 1 von 15

(from end of L05 slides) In a particular cell, a non Watson-Crick base pair (T-G) is formed during DNA replication. What is likely to happen next?

Wähle eine der folgenden:

Erklärung

Frage 2 von 15

(from end of L05 slides) How does a frameshift mutation differ from a missense mutation?

Wähle eine der folgenden:

Erklärung

Frage 3 von 15

(from end of L05 slides) Did the fluctuation test show that bacterial cells induce mutation upon exposure to the selective agent (viral infection)? Explain. (well, don’t explain *here*, but be ready to)

Wähle eine der folgenden:

Erklärung

Frage 4 von 15

DNA is replicated in:

Wähle eine der folgenden:

Erklärung

Frage 5 von 15

UV:

Wähle eine oder mehr der folgenden:

Erklärung

Frage 6 von 15

Which of the following is NOT a type of DNA mutation (necessarily)?

Wähle eine oder mehr der folgenden:

Erklärung

Frage 7 von 15

Types of mutations AT THE PROTEIN-CODING LEVEL. Fill in the blanks: Silent mutation: ❌; Missense mutation: ❌; Nonsense mutation: ❌; Frameshift ❌.

Klicke und ziehe, um den Text zu vervollständigen.

Erklärung

Frage 8 von 15

UV repair in humans is through:

Wähle eine oder mehr der folgenden:

Erklärung

Frage 9 von 15

A mutation resulting in COPY NUMBER VARIATION can vary between identical twins. Therefore it happens during:

Wähle eine der folgenden:

Erklärung

Frage 10 von 15

What does the image above show?

Wähle eine oder mehr der folgenden:

Erklärung

Frage 11 von 15

(from end of L06 slides) Variation in gene regulation = mutations that alter the amount of protein product, without a chance in the amino acid sequence. Basically a regulatory mutation. This can be in which of the following:

Wähle eine oder mehr der folgenden:

Erklärung

Frage 12 von 15

Blonde vs brown-hair is an example of variation in:

Wähle eine der folgenden:

Erklärung

Frage 13 von 15

(from end of L06 slides) Define a gene family:

Wähle eine der folgenden:

Erklärung

Frage 14 von 15

(from end of L06 slides) What is a pseudogene?

Wähle eine oder mehr der folgenden:

Erklärung

Frage 15 von 15

(from end of L06 slides) What are the 2 most likely sources of phenotypic and genomic variation between individuals within a species? (…excluding environmental factors for some reason)

Wähle eine oder mehr der folgenden:

Erklärung

(from end of L05 slides)
In a particular cell, a non Watson-Crick base pair (T-G) is formed during DNA replication. What is likely to happen next?

(from end of L05 slides)
How does a frameshift mutation differ from a missense mutation?

(from end of L05 slides)
Did the fluctuation test show that bacterial cells induce mutation upon exposure to the selective agent (viral infection)? Explain. (well, don’t explain here, but be ready to)

Types of mutations AT THE PROTEIN-CODING LEVEL. Fill in the blanks:
Silent mutation: ❌;
Missense mutation: ❌;
Nonsense mutation: ❌;
Frameshift ❌.

(from end of L06 slides)
Variation in gene regulation = mutations that alter the amount of protein product, without a chance in the amino acid sequence. Basically a regulatory mutation. This can be in which of the following:

(from end of L06 slides)
Define a gene family:

(from end of L06 slides)
What is a pseudogene?

(from end of L06 slides)
What are the 2 most likely sources of phenotypic and genomic variation between individuals within a species? (…excluding environmental factors for some reason)