According to their mechanism of action the adrenergic agonists can be divided in:
direct agonists
indirect agonists
agonists with mixed mechanism of action
natural compounds
α1-adrenoceptors are located on:
presynaptic neuronal endings
postsynaptic neuronal endings
blood vessels
iris dilator muscle
β1-adrenoceptors are located on:
myocardial cells
juxtaglomerular apparatus in the kidney
β2-adrenoceptors are located on:
bronchial smooth muscles
liver
uterus (womb)
β3-adrenoceptors are located in:
adipose tissue
urinary bladder
Pharmacological effects of Epinephrine are:
positive chronotropic effect
blood pressure elevation
bronchial smooth muscles dilation
elevated levels of blood sugar
Indications for the clinical use of Epinephrine are:
anaphylactic shock
hypoglycaemia
arrhythmia
glaucoma with wide iridocorneal angle
Potential adverse drug reactions of Epinephrine are:
tremor
anxiety and restlessness
Clinical indications for prescribing α1-agonists are:
arterial hypotension
acute rhinitis
asthma attack
heart block
Pharmacological effects of the selective β2-agonists are:
pupillary dilation
bronchial dilation
relaxation of uterine muscle
Which of the following drugs are selective β2-agonists?
lsoprenalini sulfas
Orciprenalini sulfas
Salbutamol
Salmeterol
β2-agonists are indicated in:
bronchial asthma
digitalis intoxication
arterial hypertension
threatening abortion
Adverse drug reactions of β2-agonists are:
finger tremor
bronchial dilatation
hyperglycemia
tolerance
What are the main features of the indirect-acting adrenergic agonists?
stimulation of central nervous system
drug tolerance and dependence
have no effect on the cardio-vascular system
used for treatment of narcolepsy and attention deficiency hyperactivity disorder (ADHD)
Clinically desirable interactions can occur between β2-agonists and:(find correct answer)
tricyclic antidepressants
inhaled corticosteroids
inhaled antimuscarinic drugs
beta blockers
Mechanisms of action of the presynaptic adrenolytics are:
blockade of the presynaptic α2-receptors
activation of the presynaptic α2-receptors
conversion to a “false“ neurotransmitter
blockade of the phosphodiesterase enzyme
Which of the following drugs act as agonists of the presynaptic α2-adrenoceptors?
Clonidini hydrochloridum
α-Methyldopum (Dopegyt)
Sotalol
Pharmacological effects of Clonidin are:
decreased peripheral vascular resistance
antihypertensive
inhibition of gastric secretion
antiarrhythmic
Adverse drug reactions of Clonidin are:
Dry mouth
Drowsiness and depression
Hypertensive attacks following abrupt cessation of treatment
CNS stimulation
For Methyldopa is true:
has antihypertensive effect
it is safe in pregnancy
could cause drug-induced parkinsonism
used to treat threatening abortion
Which of the following drugs are α1-adrenoblockers?
Prazosin
Doxazosin
Clonidin
Chlorpromazin
Pharmacological effects of Prazosin are:
dilation of the resistive and capacitive vessels
relaxation of the muscles in the prostate and bladder neck
hyperglycaemia
Adverse drug reactions of α1-adrenoblockers are:
orthostatic collapse
hypokalemia
fluid retention
Which of the following drugs are non-selective β-blockers?
Atenolol
Pindolol
Acebutolol
Propranolol
Which of the following drugs are selective β1-blockers?
Metoprolol
β-blockers are indicated in case of:
hypertension
ischaemic heart disease
Pharmacological effects of B-blockers are:
bronchodilation
negative inotropic effect
negative chronotropic effect
β-blocker approved for topical use in treatment of glaucoma is:
Bisoprolol
Timolol
When applied topically in the eye the B-blocker Timolol will:
increase the intraocular pressure
decrease the intraocular pressure
cause miosis
cause mydriasis
Potential adverse drug reactions of β-blockers are.
bronchoconstriction
nightmares
For long-term treatment with β-blockers is true:
up-regulation of B-adrenergic receptors
down-regulation of B-adrenergic receptors
the therapy should be ceased abruptly
the therapy should not be ceased abruptly
