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Lec 19, October 30th Gene regulation in Eukaryotes.

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Genetics Final Exam-LEC 19

Genetics Final Exam-LEC 19

Frage 1 von 10

1

What is the function of lac Y?

Wähle eine der folgenden:

  • B-Galactosidase activity

  • Permease activity

  • transacetylase activity

  • methyltransferase activity

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Frage 2 von 10

1

Allolactose binds to the promoter

Wähle eine der folgenden:

  • True

  • False

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Frage 3 von 10

1

In bacteria with genotype I+P+O+Z+Y+A+, in the presense of lactose and presense of glucose, which of the following is/are true?

Wähle eine der folgenden:

  • Transcription in on

  • Transcription is off

  • The CAP site is not occupied

  • Two of the above

  • none of the above

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Frage 4 von 10

1

Allolactose and lactose differ in the formation/type of the glycosidic bond.

Wähle eins der folgenden:

  • WAHR
  • FALSCH

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Frage 5 von 10

1

In bacteria with genotype I+P+ O^C Z+Y+A+, in the presence of lactose and absence of glucose, which of the following is/are false?

Wähle eine der folgenden:

  • Transcription is off

  • The repressor does not bind to the operator

  • The CAP site is unoccupied

  • The inducer is present

  • Two of the above

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Frage 6 von 10

1

Chromatin remodeling complexes alter nucleosomes, this occurs when:

Wähle eine der folgenden:

  • Compleses of ATP dependent protein degrade histones and release the DNA from nucleosomes

  • complexes of ATP dependent proteins may reposition, evict or change nucleosome composition

  • remodeling proteins bind to TFIID to promote or inhibit nucleosome formation

  • remodeling proteins increase the supercoiling of the DNA, which can inhibit nucleosome formation

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Frage 7 von 10

1

: (Gene)Regulatory transcription factors activate or inhinit transcription. The arrangements and composition of nucleosomes influence transcription. DNA methylation (usually) inhibits transcription.
: (pre-RNA)Alternative splicing alters exon choices. RNA editing alters the base sequence of mRNAs
: (mRNA) Small RNAs, called miRNAs and siRNAs, silence the translation of mRNA. Proteins that bind to the 5' end of mRNA regulate translation. mRNA stability may be influenced by RNA binding proteins
: (Protein) Feedback inhibition and covalent modifications regulate protein function.
Finally a Functional protein

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    Transcription
    RNA processing
    Translation
    Posttranslation modification

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Frage 8 von 10

1

What are some types of the molecular changes that undelie epigenetic gene regulation?

Wähle eine der folgenden:

  • DNA methylation and depurination of cytosine residues

  • depurination and chromatin remodeling

  • DNA methylation and chromatin remodeling

  • depurination of cytosine and thymidine residues

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Frage 9 von 10

1

DNA that contains actively transcribed genes would most likely contain chromatin in the closed configuration.

Wähle eins der folgenden:

  • WAHR
  • FALSCH

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Frage 10 von 10

1

Which of the following mRNAs would be degraded the most rapidly?

Wähle eine der folgenden:

  • an mRNA with 200 adenine residues at its 3' end

  • an mRNA with multiple AAUUU sequences in its 3' untranslated region and with 10 adenine residues at the 3' end

  • an mRNA with 100 adenine residues at its 3' end

  • an mRNA with multiple AAUUU sequences in its 3' untranslated region and with 200 adenine residues at the 3' end

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