Introduction To Haemostasis

Frage 1 von 25

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Primary Haemostasis = ❌
Secondary Haemostasis = ❌

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Formation of Fibrin Clot

Formation of Platelet Plug

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Frage 2 von 25

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Platelets are formed on the surface of which type of cell?

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Frage 3 von 25

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As a platelet has a lifespan of ( 7-10 days, 10-14 days, 14-21 days ), a patient on e.g. aspirin should have this medication stopped this period of time before surgery to avoid any unnecessary bleeding.

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Frage 4 von 25

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Platelets are formed on the surface of megakaryocytes which are found within the bone marrow

Wähle eins der folgenden:

WAHR
FALSCH

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Frage 5 von 25

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Von Willebrand Factor binds to Factor in the circulation. Without WVF the aforementioned factor would be broken down in the blood.

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Factor VIII is released from Von Willebrand Factor by action of (Factor )

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Frage 7 von 25

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Von Willebrand factor also forms part of the platelet mesh that forms in response to bleeding, holding the platelets together.

Wähle eins der folgenden:

WAHR
FALSCH

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Frage 8 von 25

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Reduced number of platelets in the blood is known as

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Frage 9 von 25

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The commonest inherited bleeding disorder is a deficiency of

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Frage 10 von 25

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Which usually results in a more serious bleed?

Wähle eine der folgenden:

Primary Haemostasis failure
Secondary Haemostasis failure

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Frage 11 von 25

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Failure of primary haemostasis typically causes which 3 of the following?

Wähle eine oder mehr der folgenden:

Epistaxis
Conjunctival bleeding
Menorrhagia
Ischaemic stroke
Coronary artery infarction

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Frage 12 von 25

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If you were concerned about the failure of primary haemostasis you would check the count in the blood.

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Frage 13 von 25

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Coagulation Cascade (1):
Tissue Factor binds with Factor

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Frage 14 von 25

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Coagulation Cascade (2):
TF-VIIa Complex activates Factor to Factor .

In the meantime, TF-VIIa also activates Factor to Factor . This Factor then binds with Factor and this complex then also activates Factor to Factor

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Frage 15 von 25

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Coagulation Cascade (3):
Factor Xa then binds with Factor to form the enzyme , which facilitates the conversion of (Factor ) to (Factor )

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Frage 16 von 25

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Coagulation Cascade (4):
Thrombin (Factor IIa) then goes about activating Factor to Factor , in turn releasing it from its binding to , whilst also activating Factor to Factor

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Frage 17 von 25

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Coagulation Cascade (5):
The main function of Thrombin, however, is in the activation of (Factor I) to (Factor Ia).

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Frage 18 von 25

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Coagulation Cascade (6):
Finally, soluble Fibrin produced by thrombin-mediated activation is organised into crosslinked Fibrin by action of Factor

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Frage 19 von 25

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Fibrin is broken down into Fibrin Degradation Products (e.g. D-dimers) via which enzyme?

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Plasminogen --> Plasmin is mediated by which enzyme, which is thus used clinically as a thrombolytic agent?

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Frage 21 von 25

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Screening tests for Fibrin Clot Formation:
❌: Tests TF-VIIa complex activating factor X so that the Xa/Va complex (prothrombinase) can be produced.
❌: Tests VIIIa/IXa complex activating Factor X so that the Xa/Va complex (prothrombinase) can be produced.

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Activated Partial Thromboplastin Time

Prothrombin Time

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Frage 22 von 25

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Anti-Thrombin III binds to ... thus inhibiting secondary haemostasis

Wähle eine der folgenden:

Thrombin (Factor IIa) only
Thrombin (Factor IIa) & Prothrombinase (Xa/Va complex)
Prothrombinase (Xa/Va complex) only
TF-VIIa & VIIIa/IXa complexes only
Thrombin (Factor IIa), Prothrombinase (Xa/Va complex) & the TF-VIIa and VIIIa/IXa complexes

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Frage 23 von 25

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Thrombin can bind to an endothelial cell forming thrombomodulin, which in turn activates Protein and Protein (give in alphabetical order).

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Frage 24 von 25

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Proteins C & S affect which complexes?

Wähle eine der folgenden:

Prothrombinase (Xa/Va complex) only
Prothrombinase (Xa/Va complex) & TF-VIIa complex
Prothrombinase (Xa/Va complex) & VIIIa/IXa complex

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Frage 25 von 25

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	Erstellt von Matthew Coulson vor mehr als 5 Jahre

Honours Degree Medicine (Haematology - Week 2) Quiz am Introduction To Haemostasis , erstellt von Matthew Coulson am 04/03/2019.

Introduction To Haemostasis

Introduction To Haemostasis

Frage 1 von 25

Primary Haemostasis = ❌ Secondary Haemostasis = ❌

Klicke und ziehe, um den Text zu vervollständigen.

Erklärung

Frage 2 von 25

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Platelets are formed on the surface of which type of cell?

Erklärung

Frage 3 von 25

Wähle von der Aufklappliste, um den Text zu vervollständigen.

As a platelet has a lifespan of 7-10 days 10-14 days 14-21 days( 7-10 days, 10-14 days, 14-21 days ), a patient on e.g. aspirin should have this medication stopped this period of time before surgery to avoid any unnecessary bleeding.

Erklärung

Frage 4 von 25

Platelets are formed on the surface of megakaryocytes which are found within the bone marrow

Wähle eins der folgenden:

Erklärung

Frage 5 von 25

Fülle die Lücke, um den Text zu vervollständigen

Von Willebrand Factor binds to Factor in the circulation. Without WVF the aforementioned factor would be broken down in the blood.

Erklärung

Frage 6 von 25

Fülle die Lücken, um den Text zu vervollständigen.

Factor VIII is released from Von Willebrand Factor by action of (Factor )

Erklärung

Frage 7 von 25

Von Willebrand factor also forms part of the platelet mesh that forms in response to bleeding, holding the platelets together.

Wähle eins der folgenden:

Erklärung

Frage 8 von 25

Fülle die Lücke, um den Text zu vervollständigen

Reduced number of platelets in the blood is known as

Erklärung

Frage 9 von 25

Fülle die Lücke, um den Text zu vervollständigen

The commonest inherited bleeding disorder is a deficiency of

Erklärung

Frage 10 von 25

Which usually results in a more serious bleed?

Wähle eine der folgenden:

Erklärung

Frage 11 von 25

Failure of primary haemostasis typically causes which 3 of the following?

Wähle eine oder mehr der folgenden:

Erklärung

Frage 12 von 25

Fülle die Lücke, um den Text zu vervollständigen

If you were concerned about the failure of primary haemostasis you would check the count in the blood.

Erklärung

Frage 13 von 25

Fülle die Lücke, um den Text zu vervollständigen

Coagulation Cascade (1): Tissue Factor binds with Factor

Erklärung

Frage 14 von 25

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Coagulation Cascade (2): TF-VIIa Complex activates Factor to Factor . In the meantime, TF-VIIa also activates Factor to Factor . This Factor then binds with Factor and this complex then also activates Factor to Factor

Erklärung

Frage 15 von 25

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Coagulation Cascade (3): Factor Xa then binds with Factor to form the enzyme , which facilitates the conversion of (Factor ) to (Factor )

Erklärung

Frage 16 von 25

Fülle die Lücken, um den Text zu vervollständigen.

Coagulation Cascade (4): Thrombin (Factor IIa) then goes about activating Factor to Factor , in turn releasing it from its binding to , whilst also activating Factor to Factor

Erklärung

Frage 17 von 25

Fülle die Lücken, um den Text zu vervollständigen.

Coagulation Cascade (5): The main function of Thrombin, however, is in the activation of (Factor I) to (Factor Ia).

Erklärung

Frage 18 von 25

Fülle die Lücke, um den Text zu vervollständigen

Coagulation Cascade (6): Finally, soluble Fibrin produced by thrombin-mediated activation is organised into crosslinked Fibrin by action of Factor

Erklärung

Frage 19 von 25

Fülle die Lücke, um den Text zu vervollständigen

Fibrin is broken down into Fibrin Degradation Products (e.g. D-dimers) via which enzyme?

Erklärung

Frage 20 von 25

Primary Haemostasis = ❌
Secondary Haemostasis = ❌

As a platelet has a lifespan of ( 7-10 days, 10-14 days, 14-21 days ), a patient on e.g. aspirin should have this medication stopped this period of time before surgery to avoid any unnecessary bleeding.

Coagulation Cascade (1):
Tissue Factor binds with Factor

Coagulation Cascade (2):
TF-VIIa Complex activates Factor to Factor .

In the meantime, TF-VIIa also activates Factor to Factor . This Factor then binds with Factor and this complex then also activates Factor to Factor

Coagulation Cascade (3):
Factor Xa then binds with Factor to form the enzyme , which facilitates the conversion of (Factor ) to (Factor )

Coagulation Cascade (4):
Thrombin (Factor IIa) then goes about activating Factor to Factor , in turn releasing it from its binding to , whilst also activating Factor to Factor

Coagulation Cascade (5):
The main function of Thrombin, however, is in the activation of (Factor I) to (Factor Ia).

Coagulation Cascade (6):
Finally, soluble Fibrin produced by thrombin-mediated activation is organised into crosslinked Fibrin by action of Factor

Screening tests for Fibrin Clot Formation:
❌: Tests TF-VIIa complex activating factor X so that the Xa/Va complex (prothrombinase) can be produced.
❌: Tests VIIIa/IXa complex activating Factor X so that the Xa/Va complex (prothrombinase) can be produced.

Deficiency of clotting factors is called
Increased tendency to form clots is called