Pharmacology I: Final Quiz

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1. MUSCLE RELAXANTS: True or false: guaifenesin selectively depresses transmission at internuncial neurons in the spinal cord, brainstem, and subcortical areas

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Which is not an effect of guaifenesin?

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Which of the following is false regarding guaifenesin?

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Which muscle relaxant requires artificial ventilation with use?

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Which type of neuromuscular block are agonists at the ACh receptor?

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Which non-depolarizing neuromuscular blockers are incorrectly matched with their duration

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Which of the following causes initial muscle fasciculation?

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Which of the following are competitive antagonists at the ACh nicotinic receptor?

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Which of the following is not a depolarizing neuromuscular blocker?

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On which of the following can you use anticholinesterase drugs to remove the effect?

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True or false: the amount of fasciculation correlates with the post-operative muscle pain

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Which of the following is not an effect of suxamethonium?

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Which of the following does not influence the effect of muscle relaxants?

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Which of the following is the most sensitive to neuromuscular blockers?

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In which species do you most commonly use neuromuscular blockers?

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HEMOSTATIC AND ANTICOAGULANTS: Which of the following hemostatics can cause extensive intravascular clotting when administered intravenously?

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What’s a good characteristic of a topical hemostatic?

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Which is used in measurement of prothrombin time during anticoagulant therapy?

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Which topical hemostatic converts endogenous fibrinogen to fibrin for clot formation?

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Which topical hemostatic can be used for bleeding from denuded mucous membranes, as an adhesive in skin grafts, and for massive blood loss?

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Which topical hemostatic is used for bleeding from parenchymatous tissue, cancellous bone, dental sockets, laryngeal/nasal surgery, reconstructive surgery, and as an adhesive agent for fixation of skin grafts?

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Is fibrin foam soluble?

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What do you use absorbable gelatin sponge/gelfoam for?

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Which of the following should only be used temporarily because otherwise you’d get fractures and cysts?

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Which are clinical uses of microcrystalline collagen?

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Which topical hemostatic produces immediate vasoconstriction and controls bleeding from small vessels?

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What’s the problem with high concentrations of styptics?

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Which systemic hemostatic is used for emergency treatment of acute hemorrhagic syndromes with deficiency of clotting factors/platelets?

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Which systemic hemostatic releases stored vWf from endothelial cell and macrophages and controls capillary bleeding from wounds?

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Which systemic hemostatic is made from fish sperm?

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Which systemic hemostatic is used to antagonize heparin-induced hemorrhagic action (since it’s basic and combines with the acidic heparin to prevent it from acting as an anticoagulant)?

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Which systemic hemostatic aids in the production of clotting factors II, VII, IX, and X and should not be given IM or IV?

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Repeated administration of which drug reduces its effectiveness?

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Which anticoagulant should you not use for laboratory diagnostic purposes?

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Which is not part of the mechanism of heparin?

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Which of these describes the action of heparin?

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Which of the following statements is false regarding heparin?

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Which of the following is false regarding vitamin K antagonists?

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Which of the following is false regarding fibrinolytic agents?

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Which of the following irreversibly binds COX in order to inhibit thromboxane A2 and prostaglandins?

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Which of the following inhibits phosphodiesterase, increasing cAMP levels in platelets, which inhibits aggregation?

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Which of the following is a P2Y12 receptor inhibitor, resulting in more cAMP and less aggregation of platelets?

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ANTICONVULSANTS: True or false: seizures are associated with episodic high frequency discharge of impulses by a group of neurons

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Which of the following neurotransmitters is not involved in epileptogenesis?

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Which of the following is a problem associated with seizures?

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Which is not a drug used in emergency treatment of seizures that stimulates GABA?

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Which of the following drugs is mismatched with its mechanism of action?

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Which of the following drugs is a GABA agonist?

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True or false: benzodiazepines decrease frequency of opening of GABA receptors.

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Which route should you not use for lorazepam or midazolam?

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Which benzodiazepine inhibits T-type calcium channels?

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What is not a side effect of barbiturates?

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True or false: barbiturates enhance GABA A by increasing the frequency of opening of the chloride channel.

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Which of the following drugs works by competing with chloride, hyperpolarizing the neuronal membranes?

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Which of the following can potassium bromide be used for?

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Which is not a mechanism of action of felbamate?

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True or false: felbamate is well absorbed from oral administration and has a wide safety margin

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Which of the following drugs has absorption depending on an L-amino acid carrier, making the process saturable?

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True or false: pregabalin has a long half life

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Which of the following drugs works by binding to SV2A?

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Which of the following drugs is partially excreted unchanged and partly glucuronidated?

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Which of the following drugs weakly inhibits GABA transaminase and has some effect on sodium and T-type calcium channels?

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Which of the following drugs is metabolized by mixed function oxidases and is well absorbed orally?

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Which of the following drugs inhibits GABA transaminase by forming an irreversible covalent bond, resulting in increased GABA?

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Which of the following is a tricyclic antidepressant with hepatic metabolism that is a strong inducer of hepatic enzymes?

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BEHAVIOR MODIFIERS: Which of the following is not an indication of psychotropic drugs in vetmed?

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Which of the following is false regarding MAOIs?

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Which of the following is not associated with serotonin syndrome?

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Which of the following is an example of an MAOI?

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Which of the following is not an adverse effect of selegiline?

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Which of the following drugs is incorrectly matched with its indication?

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7. True or false: SNRIs are metabolized via CYP450

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What isn’t an adverse effect of SNRIs?

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Which of the following is true about SNRIs according to slide 11 (e.g. generally)?

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Which of the following is not an indication for SNRI use in dogs?

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Which SNRI has analgesic properties?

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Which SNRI has equal effects on serotonin and norepinephrine?

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Which SNRI is used for separation anxiety and canine compulsive disorders?

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Which is an indication for SSRIs in cats?

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Which is not an adverse effect of fluoxetine?

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True or false: the metabolites of benzodiazepines are not active.

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True or false: in a dopaminergic synapse the enzyme beta-dopamine hydroxyls is missing

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Neuroleptics block which of the following?

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Which of the following is an incorrect example of receptor cross talk?

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True or false: progestins and estrogen suppress the excitatory effects of glutamate.

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True or false: it’s totally fine to combine MAOIs and TCAs.

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SEDATIVES AND TRANQUILLIZERS: Which is not a therapeutic target for these?

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Which is not a mechanism of action of phenothiazines?

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What is not an effect of phenothiazines?

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True or false: phenothiazines have extensive hepatic metabolism and metabolites are excreted in bile

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Which of the following is false?

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Which is false about the mechanism of action of benzodiazepines?

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Which GABA receptor subunit, when mutated, prevents binding of volatile and injectable agents?

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Which of the following is not an effect of benzodiazepines?

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True or false: benzodiazepines are reduced or glucuronidated and either excreted via the kidneys (diazepam) or both in the kidney and bile (lorazepam)

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Which benzodiazepine has active metabolites?

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In which patients should you not use benzodiazepines?

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True or false: flumazenil is a benzodiazepine antagonist that has a high affinity for the BZ-binding sites.

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Which of the following is false regarding a2 agonists?

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Which of the following is not an effect of a2 agonists?

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Which of the following is false regarding a2 agonists?

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In which animal can a2 agonists cause hypercapnia?

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In which animal does xylazine cause activation of pulmonary intravascular macrophages, resulting in acute lung injury?

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Which animal has an a2D receptor, making them more susceptible to the effects of sedatives?

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In whom can you use a2 agonists?

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Which of the following regarding a2 antagonists is true?

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Which of the following is a non-selective a-adrenergic antagonist?

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True or false: the answer to the previous question also has histaminergic and cholinergic effects

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Butyrophenone derivatives work via all of the following except:

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Which of the following is not an effect of butyrophenones?

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ANESTHESIA & ANALGESIA: Which is not a post-synaptic target for these drugs?

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Which receptor type is incorrectly matched with its number of subunits?

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Which ion blocks NMDA receptors?

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Activation of glutamate receptors requires the binding of which of the following?

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Where do almost all anesthetics potentiate the action of GABA?

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Which ion passes through the channel in the GABA receptors?

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Generally how many subunits are present in GABA receptors?

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True or false: tyrosine hydroxylase (TH) is the rate limiting step in dopamine neurotransmission

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Which of the following dopamine receptors increase adenylate cyclase activity (thereby increasing cAMP)?

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True or false: presynaptic receptors are the clinically relevant ones in the a2 adrenergic synapse (on the slide from the review…)

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HISTAMINE & SEROTONIN: Which is false regarding autacoids?

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Which of the following is not mediated by H1?

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Which of the following is an H3 effect?

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Where do you not have H4 receptors?

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Which of the following is false regarding the production of histamine?

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Which of the following is true regarding histamine stores?

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In order to release histamine from mast cells, the cells must become more permeable to which ion?

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Which of the following is not a role of histamine?

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Which is not an effect of histamine on the cardiovascular system?

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Which of the following is true regarding histamine-mediated vasodilation?

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In which group of animals does histamine relax bronchial smooth muscle?

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Which other smooth muscles are contracted by histamine?

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Which of the following is true?

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Which of these other receptors has the same pathway as endothelial H1 receptors?

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True or false: histamine is poorly absorbed from parenteral administration

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Which is NOT part of the the metabolism of histamine:

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Which of the following is false regarding histamine agonists?

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Which of the following will give you CNS sedation?

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Which of the following lacks antimuscarinic effects?

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Which of the following is false regarding the pharmacokinetics of antihistamines?

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Which is not a pharmacologic effect of antihistamines?

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What is not a therapeutic use of antihistamines in bovines?

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Which of the following is not a therapeutic use of antihistamines?

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Which antihistamine can cause polyphagia, sedation, increased vocalization, and vomiting in cats?

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True or false: antihistamines can cause hyperexcitability and convulsions at high doses

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Which is false regarding cromolyn sodium?

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True or false: serotonin is derived from tryptophan

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Which of the following serotonin receptors is mismatched with their mechanism?

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Which of the following is false regarding the triphasic response to rapid IV injection of serotonin?

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Which of the following is not caused by serotonin?

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Which of the following is not an SSRI?

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Which of the following serotonin agonists would you use to control postpartum hemorrhage and for uterine involution? (Hint: it’s an agonist of the 5-HT2 receptor!)

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Which drug is used for constipation and megacolon in cats? (But let’s be honest here, all I care about is its use for stasis in rabbits.)

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Which drug is an agonist of the 5-HT4 receptor and a D2 antagonist that, while being useful for gastric stasis and anti-emesis, can also change your mood/behavior?

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Which antagonist of the 5-HT1 receptor (and first gen antihistamine) is used for head shaking in horses and feline asthma?

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Which of the following is an antagonist of the 5-HT2 receptor and alpha adrenergic receptor, antihistamine, and is used for glaucoma?

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Which drug (that sounds like a transformer) is used as an antiemetic during chemotherapy?

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Which 5-HT2 antagonist is used for carcinoid syndrome (cancerous tissues producing too much serotonin)?

Final Pharmacology I Quiz from Veterinary Pharmacology I taught by Dr. Werners, and Lady Dr. Kumar

Pharmacology I: Final Quiz

1. MUSCLE RELAXANTS: True or false: guaifenesin selectively depresses transmission at internuncial neurons in the spinal cord, brainstem, and subcortical areas

Which is not an effect of guaifenesin?

Which of the following is false regarding guaifenesin?

Which muscle relaxant requires artificial ventilation with use?

Which type of neuromuscular block are agonists at the ACh receptor?

Which non-depolarizing neuromuscular blockers are incorrectly matched with their duration

Which of the following causes initial muscle fasciculation?

Which of the following are competitive antagonists at the ACh nicotinic receptor?

Which of the following is not a depolarizing neuromuscular blocker?

On which of the following can you use anticholinesterase drugs to remove the effect?

True or false: the amount of fasciculation correlates with the post-operative muscle pain

Which of the following is not an effect of suxamethonium?

Which of the following does not influence the effect of muscle relaxants?

Which of the following is the most sensitive to neuromuscular blockers?

In which species do you most commonly use neuromuscular blockers?

HEMOSTATIC AND ANTICOAGULANTS: Which of the following hemostatics can cause extensive intravascular clotting when administered intravenously?

What’s a good characteristic of a topical hemostatic?

Which is used in measurement of prothrombin time during anticoagulant therapy?

Which topical hemostatic converts endogenous fibrinogen to fibrin for clot formation?

Which topical hemostatic can be used for bleeding from denuded mucous membranes, as an adhesive in skin grafts, and for massive blood loss?