An overview of the clotting cascade:
1. Initiation:
Platelets adhere to vessel and ❌ more circulating platelets to ❌. This provides a surface
where clotting factors assemble. Some clotting factors are ❌. TF initiates coagulation. TF activates ❌, forming Xa and IXa.
2. Amplification
IXa amplifies the activation of ❌. The ❌ complex is a critical component, activating ❌ (thrombin)
3. Propagation
A burst of activated thrombin then converts ❌, to form a mesh.
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fibrinogen to fibrin
fibrinogen to fibrin