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What is the fundamental characteristic of bone and what other roles does it play in the body?
What are the 5 different bone types? (Give an example of each)
What are bones composed of?
What is the organic matrix composed of? What are its properties?
What is the main mineral of bone?
What is new, un-mineralised bone called? What is its common characteristics?
Name 3 determent's of bone strength.
What are osteoprogenitor cells and what do they do?
What are osteoblasts and what is their main job?
What other jobs do osteoblasts do?
What is the difference between osteoblasts, osteocytes and bone lining cells?
What are osteocytes and what do they do?
What are osteoclasts and what do they do?
How does bone resorption work?
How is bone resorption limited to one area?
What is the proper term for compact bone?
What is cortical bone and where is it found?
What is osteocytic osteolysis?
What is the more formal term for spongy bone?
What is trabecular bone and where is it found
What 'disease' occurs when the rate of bone resorption exceeds the rate of bone synthesis over a fair period of time?
What is the protein matrix of bone composed of?
Name the 3 main types of osteoblast-derived proteins are found in the extracellular matrix?
What is important to know about type 1 collagen?
How is collagen laid down in bone formation?
What is osteocalcin and where is it found?
What is osteonectin and where is it found?
Signalling pathways allow bone cells and locally produced factors to regulate homeostasis. What are the 3 pathways?
What does the RANK ligand pathway do?
How does the RANKL pathway work?
How does the M-CSF (Macrophage Colony Stimulating Factor) pathway work?
What does the WNT/beta-catenin pathway do?
Osteoblasts can enhance/inhibit osteoclast development and function by expressing OPG and RANKL at different levels. What factors effect this expression?
