NE1 Intro and CNS revision

Message from brain or spinal cord to the muscles, organs is ❌.
Message from receptors to the brain or spinal cord is ❌.
Interneuron relays between ❌ neurons.
Information flows from one neuron to another across a synapse, changing ❌ to ❌ and back.
• Target cell MORE likely to fire = ❌
• Target cell LESS likely to fire = ❌
❌ = ‘decides’ whether to fire AP
❌ summation: different locations at same time
❌ summation: same place, slightly different times

Neurotransmitters:
Conventional -
1. Small molecules
• Amino acids: ❌
• Biogenic amines: ❌ noradrenaline, serotonin, histamine
• Purines: ❌
2. ❌
3. Neuropeptides: ❌ Neuropeptide Y

Non conventional -
1. ❌
2. Gasotransmitters: ❌

Drugs affecting dopaminergic neurons:
Synthesis - ❌ facilitates synthesis of DA by acting as a precursor - agonist
Storage - ❌ blocks DA uptake into vesicles – antagonist
Action - ❌ prolongs action of DA by blocking degradation (MAO-B inhibitor) - agonist
Release - Amphetamine increases release of DA - agonist
Reuptake - ❌ and amphetamine blocks DA reuptake - agonist

Drugs affecting serotonergic(5-HT) neurons:
Synthesis - α-Methyltyrosine inhibits synthesis of 5-HT - antagonist
Release - ❌ facilitates the release of 5-HT - agonist
Reuptake - ❌ blocks reuptake of 5-HT- agonist