Which are the main drug groups for treatment of ulcer disease
antacids drugs
anti-secretion drugs
gastro-duodenal protectors
drugs against HP infections
Which are non-absorbent antacid drugs
sodium salts
calcium salts
aluminium salts
magnesium salts
Which are anti-secretion drugs
Proton pump inhibitors
H2-histamine blockers in stomach mucosa
M3-cholinergic blockers in stomach mucosa cells
COX inhibitors
Which drugs are used for eradication of Helicobacter pylori-infections
proton pump inhibitors
colloidal bismuthi salts
histamine blockers
antibacterial drugs
Proton pump inhibitors are
Omeprazole
Rabeprazole
Mizoprostol
Lansoprazole
Gastrointestinal mucosa protectors are
Sucralphate
Misoprostol
Probiotics
Colloidal bismuths salts
Well known drug interactions of proton pump inhibitors are
decreased absorption of some antibiotics as tetracyclines, isoniazid, ciprofloxacin
decreased absorption of some other drugs as digoxin, quinidine, theophylline, NSAIDs, warfarin
increased absorption of some antibiotics as tetracyclines, isoniazid, ciprofloxacin
increased absorption of other drugs as digoxin, quinidine, theophylline, warfarin
Drugs contraindicated during pregnancy or breast feedings are
Bismuth salts
Antacid drugs
Maintenance therapy is indicated for patients with
complicated chronic ulcer disease with bleeding and perforations
concomitant erosive reflux esophagitis or reflux gastritis
patients over 50 years of age and concomitant diseases requiring often usage of NSAIDs or other drugs irritating stomach or duodenal mucosa
chronic tobacco smokers or people with liver cirrhosis, chronic obstructive lung disease etc.
Corrections of dose regimen are recommended for
H2-histamine blockers treatment (Cimetidine or Ranitidine) for patients with liver insufficiency
H2-histamine blockers in patients with kidney insufficiency
Proton pump inhibitors in patients with liver insufficiency due to prolonged half-life
Proton pump inhibitors in patients with kidney insufficiency
