Courtney Walsh
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DVM Clin Path Quiz am Clin Path-Lymphocytes, erstellt von Courtney Walsh am 04/02/2020.

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Courtney Walsh
Erstellt von Courtney Walsh vor fast 5 Jahre
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Clin Path-Lymphocytes

Frage 1 von 30

1

: a self-renewing cell which gives rise to committed stem cells when stimulated.

: stem cells committed to production of a single cell type (for example, eosinophils). An exception to this is CFU-GM (colony forming unit - granulocyte-monocyte), which splits further into neutrophil and monocyte producing stem cells.

: a young undifferentiated cell with one or more visible nucleoli. It is one step beyond the CFU stage and can be recognized in bone marrow aspirates as rubriblasts or myeloblasts.

: a white blood cell (leukocyte) with cytoplasmic granules (neutrophil, eosinophil and basophil). Therefore, lymphocytes and monocytes are leukocytes but are not granulocytes. This designation ignores the fact that some lymphocytes contain granules, but life isn=t perfect, is it?

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    Pluripotent stem cell
    Colony forming units (CFU)
    Blast cell
    Granulocyte

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Frage 2 von 30

1

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2 types of neutrophils are present in the circulation of a healthy animal: the vast majority are mature neutrophils, with a few neutrophils also seen. Higher numbers of signify inflammation.
In clinical pathology, we mean a segmented neutrophil if we just say neutrophil and band neutrophils are specifically called bands or band neutrophils.
Segmented neutrophils have a segmented nucleus (with a dark condensed chromatin pattern) connected by thin strands.
Segmented neutrophils from female animals may have a - a drumstick shaped extension of the nucleus.
Band neutrophils classically have a U-shaped nucleus (can be other shapes, such as C or S shaped).
Cytoplasm of neutrophils is typically or very faintly pink or blue - granules are present but they are not usually possible to see with a light microscope.
The same cell type in birds, fish, rats, guinea pigs and rabbits have staining granules and are sometimes (not always, depends on the reference) called . The current preferred term is still neutrophils

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Frage 3 von 30

1

Select all the following that may cause neutrophilia

Wähle eine oder mehr der folgenden:

  • toxins

  • neoplasia

  • fungal and viral infections

  • immune-mediated disease

  • all can cause neutrophilia

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Frage 4 von 30

1

Which of the following is part of the proliferation pool of neutrophils?

Wähle eine der folgenden:

  • myeloblast

  • metamyelocytes

  • band neutrophil

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Frage 5 von 30

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Select the following that are stages of neutrophil life stages?

Wähle eine oder mehr der folgenden:

  • bonemarrow

  • intravascular

  • tissue

  • diapedetic

  • adhesion

  • proliferation

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Frage 6 von 30

1

In most species, approximately equal numbers of neutrophils in the blood are in the circulating (50 %) and marginating (50 %) pools

Wähle eins der folgenden:

  • WAHR
  • FALSCH

Erklärung

Frage 7 von 30

1

In most species, approximately equal numbers of neutrophils in the blood are in the circulating ( %) and marginating (50 %) pools. The cat differs in that ~ % of blood neutrophils are in the marginating pool, with only ~ % freely circulating.

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    75
    25
    50

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Frage 8 von 30

1

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It generally takes - days before you will see any evidence of increased segmented neutrophil numbers in the bloodstream as a result of increased bone marrow production.

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Frage 9 von 30

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Which of the following is not a morphological characteristic of monocytes?

Wähle eine der folgenden:

  • mottled lacy chromatin pattern

  • round to lobulated nucleus

  • crisp vacuoles in the cytoplasm

  • grey-neutral staining cytoplasm

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Frage 10 von 30

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monocytes are short-lived cells that remain in the tissue and can produce more macrophages.

Wähle eins der folgenden:

  • WAHR
  • FALSCH

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Frage 11 von 30

1

Connective tissue histiocytes, osteoclasts, microglial cells in the nervous system, Kupffer cells in the liver and Langerhan's cells in the skin are all examples of tissue fixed monocytes

Wähle eins der folgenden:

  • WAHR
  • FALSCH

Erklärung

Frage 12 von 30

1

which of the following does NOT cause increased monocytosis?

Wähle eine der folgenden:

  • trauma

  • excitement

  • stress

  • type 1 hypersensitivity reactions

Erklärung

Frage 13 von 30

1

a marked monocytosis is often seen with acute inflammation

Wähle eins der folgenden:

  • WAHR
  • FALSCH

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Frage 14 von 30

1

neutrophils, eosinophils and basophils cannot be differentiated visually until the myelocyte stage when specific granules appear

Wähle eins der folgenden:

  • WAHR
  • FALSCH

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Frage 15 von 30

1

Eosinophilia due to parasites occurs only when sensitivity to parasite proteins has developed and these proteins are then exposed to body tissues or the bloodstream to trigger an increase in eosinophil production and release into the blood.

Wähle eins der folgenden:

  • WAHR
  • FALSCH

Erklärung

Frage 16 von 30

1

basophils

Wähle eine der folgenden:

  • have a segmented nucleus like neutrophils and eosinophils

  • The nuclear chromatin is more condensed than in neutrophils

  • often make up 10 % of a differential count in a normal animal.

Erklärung

Frage 17 von 30

1

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Basophils, like mast cells, they are involved in immediate (type 1) hypersensitivity reactions.
• When a specific antigen binds to bound to the basophil surface, degranulation and release of granule components occurs.
• Granules contain numerous substances, including and heparin

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Frage 18 von 30

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After neutrophils, these are the most common circulating leukocyte in domestic animals, including mature cattle

Wähle eine der folgenden:

  • monocytes

  • basophils

  • lymphocytes

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Frage 19 von 30

1

Which of the following is FALSE regarding Production and kinetics of lymphocytes?

Wähle eine der folgenden:

  • They are not stored in the marrow

  • A unique feature of lymphocytes is that they

  • lifespan of lymphocytes is generally longer than for other cells

  • causes of mild to moderate lymphocytosis include cortisol release or antigenic stimulation

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Frage 20 von 30

1

Which of the following can alter WBC count numbers?

Wähle eine der folgenden:

  • nucleated RBC's

  • thrombocytopenia

  • age of patient

  • sex of patient

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Frage 21 von 30

1

Which of the following statements regarding neutrophil toxicity is true?

Wähle eine der folgenden:

  • • Neutrophil toxicity is evidence that systemic toxins are present in the body. Since neutrophil toxicity is a sign of abnormal maturation of neutrophil cytoplasm, it indicates that the microenvironment of the marrow was not ideal when those cells were being produced.

  • The causes of neutrophil toxicity include endogenous toxins (such as inflammatory mediators) and exogenous toxins

  • Neutrophil toxicity is characterized by cytoplasmic changes, whereas neutrophil degeneration is characterized by nuclear changes

  • All are correct

  • None are true

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Frage 22 von 30

1

Degenerate neutrophils were once normal but have been altered at the tissue site. Toxic neutrophils were never normal since the alteration is one of cytoplasmic maturation.

Wähle eins der folgenden:

  • WAHR
  • FALSCH

Erklärung

Frage 23 von 30

1

These are pale blue-grey variably shaped and shaped aggregates of abnormal rough endoplasmic reticulum in the cytoplasm. They are one of the earliest changes to occur with toxicity, so they can be seen in any situation of mild toxicity

Wähle eine der folgenden:

  • Dhole bodies

  • foamy basophilia

  • toxic granulation

Erklärung

Frage 24 von 30

1

This is due to escape of hydrolytic enzymes and the presence of increased amounts of basophilic staining RNA. The cytoplasm has a foamy appearance and is more blue than normal.

Wähle eine der folgenden:

  • cytoplasmic foamy basophilia

  • toxic granulation

  • dhole bodies

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Frage 25 von 30

1

Physiologic leukocytosis
-Mild without a left shift
-Lymphocytes are most often mildly to moderately
-no evidence of monocytosis

Corticosteroid (stress) response
-neutrophilia with
- often mild to marked
-

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    neutrophilia
    increased
    monocytosis
    no left shift
    lymphopenia

Erklärung

Frage 26 von 30

1

Fülle die Lücken, um den Text zu vervollständigen.

Protein/fibrinogen ratios are calculated as P/F or rarely as (P-F)/F
• If the reason for the increased fibrinogen concentration is dehydration, the total protein concentration should also be increased, and the P/F ratio will be or higher.
• If the reason for the increased fibrinogen concentration is inflammation, the total protein concentration will not rise proportionately, and the P/F ratio will be or less.
• If we calculate a P/F ratio of -, we cannot really make any conclusions (grey zone).

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Frage 27 von 30

1

If you see a low (<10) P/F ratio

Wähle eine der folgenden:

  • inflammation!

  • Dehydration!

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Frage 28 von 30

1

There is individual variability in P/F ratios in animals

Wähle eins der folgenden:

  • WAHR
  • FALSCH

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Frage 29 von 30

1

select the following responsible for neutropenia

Wähle eine oder mehr der folgenden:

  • genetic disease

  • toxins

  • excitement

  • bone marrow insufficiency

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Frage 30 von 30

1

in cattle specifically, which would cause lymphocytosis?

Wähle eine der folgenden:

  • BLV

  • genetic bone marrow hyperactivity

  • chronic leukemia

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