Hannah-Marie Rhodes
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Pathology Quiz am Inflammation and Wound Healing - L6-7, erstellt von Hannah-Marie Rhodes am 12/02/2020.

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Hannah-Marie Rhodes
Erstellt von Hannah-Marie Rhodes vor mehr als 4 Jahre
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Inflammation and Wound Healing - L6-7

Frage 1 von 24

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How do you describe an organ that is inflamed?

= inflammation of that tissue

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Frage 2 von 24

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Acute Inflammation

Wähle eine oder mehr der folgenden:

  • mediated by Interleukin-1 and other cytokines

  • Systemic response to severe injury or inflammation

  • To over come the cause of Inflammation (occurring after the other type of inflammation fails)

  • Walls off area with fibrous connective tissue

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Frage 3 von 24

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Chronic Inflammation

Wähle eine oder mehr der folgenden:

  • Walls off the area with fibrous connective tissue

  • Mediated by Interleukin-1 and other cytokines

  • Systemic response to severe injury or inflammation

  • To over come the cause of Inflammation (occurring after the other type of inflammation fails)

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Frage 4 von 24

1

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What are the five classical signs associated with Inflammation?
1.
2.
3.
4.
5.

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Frage 5 von 24

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Changes occurring during the vascular phase of acute inflammation

1.
Capillary beds
Signs associated: and

2.
Chemical mediators are released
Fluid flows through the
Signs associated:

3.
Blood is more - the flow
Increase in and in the area

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    Vasodilation of arterioles
    Contraction of endothelial cells
    Leakage of Fluid
    viscous
    Heat
    Redness
    gaps into the extracellular space
    Swelling
    Slows
    RBC
    WBC
    causing contraction of endothelial cells
    distend with blood

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Frage 6 von 24

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Functions of the vascular phase

1.
2.
3.
4.

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Frage 7 von 24

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Changes occurring during the cellular phase of inflammation

1.
Slowing of blood during the vascular phase - leukocytes contact endothelial cells

2.
2a.
2b.
2c. and
2d.
2e.

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    Margination
    Emigration
    Tethering
    Rolling
    Activation
    firm adhesion
    Transmigration
    Chemotaxis

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Frage 8 von 24

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Functions of the cellular phase

1.
2.
3. to
4.

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Frage 9 von 24

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What are the Leukocytes associated with inflammation?

1.
2.
3.

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Frage 10 von 24

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What are the four different inflammatory exudates?

1. exudate
, low in

2. Inflammation
Fibrinogen -->
present

3. Inflammation
Mucus
Due to inflammation of

4. or Inflammation

Lot of , and

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    Serous
    Watery fluid
    protein
    clots
    Neutrophils
    Catarrhal
    mucous membranes
    Suppurative
    Purulent
    Pus
    neutrophils
    fluid
    necrotic debris
    Fibrinous

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Frage 11 von 24

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What is the purpose of inflammatory mediators?

Be the that , or inflammation

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Frage 12 von 24

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Demolition Phase

What: The after the fluid and cellular phases

Processes occurring: and

Processes function: To

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    breakdown and removal of necrotic tissue
    Liquefaction
    Phagocytosis
    prepare for repair and regeneration

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Frage 13 von 24

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What are the outcomes of acute inflammation?

1.
If injury is and there is
Damage is or

2.
OR occurs when there is lots of tissue destruction or they cant regenerate

3.
If the cause of OR
Something

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Frage 14 von 24

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Four phases of wound healing

1.
AIM:
--> -->

2.
present
remove

3. &
AIM:
produce --> of epi. cells and fibroblasts
Granulation tissue =

4.
Once inflammation finished & new tissue forms -

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    Homeostasis
    Acute Inflammation
    Granulation tissue formation
    replacement of epithelial tissue cells
    Wound maturation and Remodeling
    To prevent further bleeding
    by blood clotting
    Vessel constriction
    Platelet plug
    Fibrin plug
    Classical signs of inflammation
    Neutrophils and Macrophages
    debris from injury
    Fill in gap of damaged tissue
    fibrous connective tissue + capillaries
    granulation tissue is replaced by mature
    connective tissue
    macrophages
    growth factors
    proliferation

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Frage 15 von 24

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Healing by First Intention
+

Occurs if:
Minimal
Minimal

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Frage 16 von 24

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Healing by second intention
- , ,

Occurs when:
Greater

Wound edges
present

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Frage 17 von 24

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Process of wound contraction
Feature of
Wound margins

-
-
- Continues

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    2nd Intention
    grow towards each other
    Myofibroblasts at edges contract
    bringing edges together
    Makes smaller wound to fill with
    granulation tissue and epithelial cells
    after re-epithelialisation

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Frage 18 von 24

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Factors affecting wound healing

1.
2.
3.
4.
5.
6.

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Frage 19 von 24

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What are the events involved in fracture repair?
1.
2.
3.
4.

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Frage 20 von 24

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What are the factors that affect fracture healing?

1.
2.
3.

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Frage 21 von 24

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Antigen:
substance that or

Antibody:
in response to or

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Frage 22 von 24

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Hypersensitivity reactions P1

Type I = Hypersensitivity
Due to
Occurs within
Reactions directed against
activation of , &
Mediators that cause: , --> ,

E.g (Hay fever)

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    Immediate
    IgE antibodies
    minutes of repeat exposure
    seconds of repeat exposure
    antigens from enviro & parasites
    mast cells
    basophils
    eosinophils
    smooth muscle spasm
    oedema
    swelling
    excessive mucus secretion
    Allergic Rhinitis
    Rhinitis Allergic

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Frage 23 von 24

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Hypersensitivity reactions P2

Type II = hypersensitivity
Formation of of the
Leads to the

E.g.

Type III = hypersensitiviity
Occurs due to
These
Neutrophils release into tissue - damage tissue
commonly occurs in the , , and

E.g. (SLE)

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    Antibody mediated
    Immune complex
    Immune mediated haemolytic anaemia
    Lupus
    antibodies directed against antigens
    surface of a cell or tissue
    cell being destroyed
    formation of antigen-antibody complexes
    in bloodstream
    get stuck in capillaries
    toxic free radicals and enzymes
    joints
    glomeruli
    eye
    blood vessels

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Frage 24 von 24

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Immunological Test
Measures - checks the
E.g.

Serological Test
Based on the ability to detect reactions from the
E.g. S

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