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Multicellularity requires communication between cells;
cells in multicellular organisms have a number of decisions to make:
Signalling routes:
Endocrine pathway
Signalling routes:
paracrine pathway
Signalling routes:
Neuronal pathway
Signalling routes:
contact-dependent
Examples of signalling factors
Signal transduction
2 things that can happen intracellularly in response to binding
Receptors
Receptors:
cell surface receptors
Receptors:
intracellular receptors
Major membrane receptor families
Receptors:
ion channels
Receptors:
G protein-coupled receptors
GPCRS
action of G-protein-coupled receptors
cAMP
Example of a G-protein coupled receptor pathway:
reaction of cells to adrenaline; the 'fight or flight' hormone
G-protein coupled receptor activation:
Receptor activation of protein kinase C (PKC)
Summary:
the 2 different G-protein coupled receptor pathways
Receptor kinase pathway
