Test 2 Question 25. Which one of the following statements is true regarding atypical antipsychotics?
Ziprasidone is an agonist at the serotonin (5-HT) 1A receptor and an inhibitor of reuptake of both serotonin and norepinephrine
Risperidone is a significantly weaker antagonist of the dopamine D2 receptor than haloperidol
Quetiapine is known for its high incidence of extrapyramidal symptoms
Olanzapine has been associated with weight loss in the majority of patients
Clozapine has been shown to increase suicidality in chronically ill patients
Test 2 Question 27. Which of the following is not a side effect of the tricyclic antidepressants?
Tachycardia
Prolonged PR interval
Prolonged QRS interval
Orthostatic hypotension
Diarrhea
Test 2 Question 29. Which one of the following antidepressants can be used as an antipruritic agent and for the treatment of gastric ulcer because of its potent histamine blockade?
Trazodone
Fluoxetine
Citalopram
Amitriptyline
Amoxapine
Test 2 Question 59. Which of the following is not a tricyclic antidepressant?
Doxepin
Desipramine
Nortriptyline
Test 2 Question 64. Carbamazepine will not lower the levels or the efficacy of which one of the following agents?
Warfarin
Clozapine
Alprazolam
Propranolol
Test 2 Question 66. Patients who smoke tobacco heavily can markedly reduce levels of psychotropic medications they are taking. Which one of the following medications is not affected by tobacco smoking in this way?
Olanzapine
Haloperidol
Risperidone
Test 2 Question 96. Buspirone’s mechanism of action is predominantly linked to which one of the following receptors?
Serotonin 2A
Serotonin 1A
N-methyl-d-aspartate (NMDA)
Dopamine 2
NE
Test 2 Question 100. Which one of the following agents is least likely to exacerbate the extrapyramidal symptoms of Parkinson’s disease?
Perphenazine
Thorazine
Fluphenazine
Phenelzine
Test 2 Question 107. Which one of the following tricyclic antidepressants is not considered a tertiary amine?
Imipramine
Clomipramine
Trimipramine
Test 2 Question 109. The metabolite of which one of the following tricyclic antidepressants has potent dopamine-blocking ability that can lead to antipsychotic-like side effects?
Test 2 Question 111. Interaction with the enzyme cytochrome P450 (CYP) 2D6 has what bearing on the use of tricyclic antidepressants?
None; tricyclics do not interact with CYP 2D6
Those with decreased CYP 2D6 activity will have lower than expected plasma drug concentrations
Giving a patient on a tricyclic a CYP 2D6 inhibitor could cause a drop in the plasma concentration of the drug
Cimetidine can cause an increase in tricyclic levels as a result of its interaction with CYP 2D6
Concomitant use of drugs that inhibit CYP 2D6 with tricyclics may necessitate higher than usual prescribed doses of either drug to obtain the same levels
Test 2 Question 121. Which one of the tricyclic antidepressants has the most antihistaminic activity?
Test 2 Question 122. Which one of the following is not helpful in the treatment of obsessive–compulsive disorder?
Bupropion
Fluvoxamine
Sertraline
Test 2 Question 123. Which one of the following is true regarding the tricyclic antidepressants?
The downregulation of β-adrenergic receptors correlates most closely with time needed for clinical improvement in patients
Giving tricyclics leads to an increase in β-adrenergic receptors
Giving tricyclics leads to an increase in 5-HT receptors
Giving tricyclics leads to an increase in β-adrenergic receptors and a decrease in 5-HT receptors
Giving tricyclics leads to a decrease in β-adrenergic receptors and an increase in 5-HT receptors
Test 2 Question 126. Patients with which one of the following disorders may have clinically significant side effects from tricyclic antidepressant drugs?
Insomnia
Benign prostatic hypertrophy
Migraine
Parkinson’s disease
Pituitary adenoma
Test 2 Question 133. Which one of the following is among the least sedating of the tricyclic antidepressants?
Test 2 Question 137. Caution should be taken when prescribing which one of the following to a woman on oral contraception?
Valproic acid
Gabapentin
Lithium
Carbamazepine
Test 2 Question 141. Which one of the following is not a potential repercussion of lithium intoxication?
Seizure
Renal toxicity
Ataxia and coarse tremor
Nonspecific T-wave changes
. Jaundice
Test 2 Question 143. Which one of the following is not true regarding use of the tricyclic antidepressants?
Owing to their ability to prolong cardiac conduction time their use in patients with conduction defects is contraindicated.
These agents should be discontinued before elective surgery because they may cause hypertensive episodes during surgery
Some patients who experience orthostatic hypotension may respond to the use of fludrocortisone
Myoclonic twitches and tremors of the tongue and upper extremities are common in some patients on tricyclics
Amoxapine is the least likely to cause parkinsonian symptoms of all the tricyclics
Test 2 Question 145. Which one of the following antidepressants is the most serotonin-selective of the tricyclics?
Test 2 Question 147. Which one of the following is not a side effect of treatment with tricyclic antidepressants?
Termination of ventricular fibrillation
Increased collateral blood supply to ischemic heart muscle
Decreased contractility
Hypertension
