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True or False
LA and Analgesics work in a similair way with almost identical effects
How do Local Anesthetics work?
Tetradotoxin
Saxitoxin
Centruriodes
- Homatropine
What are the 3 parts that make up the structure of most LA
SAR: Intermediate Chain
SAR: Aromatic Ring
Analyze its LA activity
SAR: Hydrophilic Portion
Name the LA with chiral centers
Name the LA that are marketed in their Levo form
True or False
The Levo isomer shows significant decrease in CNS and cardiotoxicity
True or False
Amide and ester type LA can be sterilized using heat
- Describe the relationship between lipophilicity and
1) Onset of Action
2) Water Solubility
3) Potency
4) DOA
5) Toxicity
- Administration of LA in a carbonic acid-carbondioxide solution as suppose to hydrochloride salt would improve time of onset and DOA, however it is unpractical...Why?
Side effects of LA
DDI
