What is the most common cancer in males?
Non Melanoma Skin Caner
Prostrate cancer
Lung cancer
Colorectal
What is the most common cancer in females?
Breast cancer
Non Melanoma Skin Cancer
Colorectal cancer
How do Tobacco smoke and coal tar form cancer?
Forming aldehyde adducts
Forming DNA adducts
Exposure to what substances increases the liver cancer incidence?
Aflatoxin B1 and Hepatitits B
alcohol and tobacco
Protooncogene inheritance is classified as
Loss of function
Gain of function
Both
None of the above
Tumor suppressor gene inheritance is classified as?
In Familial cancer syndrome what is the gene that is mutated?
RET
MET(HGFR)
BCR
ABL
In Hereditary renal papillary carcinoma what is the gene that is mutated?
MET (HGFR)
What is the translocation in follicular lymphoma
14:18
15:17
9:22
11:22
CML translocation is seen between what chromosomes?
What translocation is seen in Promyelocytic leukemia?
Translocation in Ewing's Sarcoma?
How does translocation cause cancer?
The novel product promotes proliferates like an oncogene
It makes a transcription factor that promotes proliferation
It makes a novel factor that inhibits apoptosis
N-MYC is amplified in what tumor?
Neuroblastoma
Pheochromocytoma
Wilms tumor
In Knudson's 2 hit model what are the mechanisms for the second hit?
Loss of heterozygosity
Deletion
recombination
non-dysjunction
All of the above
Which of the following is not inherited by Autosomal Dominance?
Retinoblasotma
Li-Fraumeni Syndrome
Hereditary Breast cancer
Neurofibromatosis 1
FAP / HNPCC
What are the mutations in FAP?
APC
What are the mutations in HNPCC?
MLH 1 and 3
MSH 2 and 6
PMS 1 and 2
Wnt binds to Frizzled and activates dishevelled which in turn inhibits APC/Axin/GSK-3Beta
Beta Catenin is not phosphorylated so not destroyed so it accumulates and promotes proliferation
Microsatellite instability/ replication error positive is seen in HNPCC - true or false
What are the mutations that are seen in sporadic cancer?
PTEN
TGFBR2
SMAD4
WT1
In Xeroderma Pigmentosum the most common nucleotide repair mechanism is excision endonuclease deficiency - true or false?
In Ataxia Telegectasia (ATM) mutation of what gene promotes proliferation?
p53
RB
myc
none of the above
Bloom syndrome - DNA helicase deficiency - true or flase
