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phar530 assessment 1.2 practice

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Assessment 1.2 Practice

Assessment 1.2 Practice

Frage 1 von 80

1

Which of the following drug substance properties is important for capsule size selection?

Wähle eine der folgenden:

  • Melting Point

  • Bulk density

  • Particle Size

  • Drug solubility

Erklärung

Frage 2 von 80

1

Which of the following is not part of Capsule Quality Control program

Wähle eine der folgenden:

  • Drug Content

  • Friability Test

  • Dissolution test

  • Fill Weight

  • Disintegration Test

Erklärung

Frage 3 von 80

1

The stability dating requirements of USP 795 for the extemporaneous compounding of capsules are

Wähle eine der folgenden:

  • 4 months if prepared from USP/NF ingredients or 25% of remaining expiration dating if prepared from commercial products

  • 6 months if prepared from USP/NF ingredients or 50% of remaining expiration dating if prepared from commercial products

  • 2 months if prepared from USP/NF ingredients or 25% of remaining expiration dating if prepared from commercial products

  • 6 months if prepared from USP/NF ingredients or 25% of remaining expiration dating if prepared from commercial products

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Frage 4 von 80

1

For human use, eight capsule sizes are available ranging from:

Wähle eine der folgenden:

  • the smallest No. 000 to the largest No.5.

  • the smallest No. 5 to the largest No. 000

  • the smallest No. 01 to the largest No. 08.

  • the smallest No. 1 to the largest No. 8

Erklärung

Frage 5 von 80

1

The coni-snap® hard gelatin capsules have a unique design that:

Wähle eine der folgenden:

  • Enables the two halves of the capsule shell to fit like a lock and key.

  • Enables the two halves of the capsule shell to be fit together by strong compression forces.

  • Enables the two halves of the capsule shell to be positively joined through locking grooves in the shell walls.

  • Enables the two halves of the capsule shell to be sealed with strong polymer adhesive

Erklärung

Frage 6 von 80

1

The USP content uniformity test for capsules specifies that:

Wähle eine der folgenden:

  • 9 out of 10 capsules are within 80% to 120% of labeled drug amount

  • 9 out of 10 capsules are within 85% to 115% of labeled drug amount

  • 9 out of 10 capsules are within 70% to 125% of labeled drug amount

  • 9 out of 10 capsules are within 75% to 125% of labeled drug amount

Erklärung

Frage 7 von 80

1

Substances that absorb moisture from the air to the extent that they liquefy are called

Wähle eine der folgenden:

  • Deliquescent

  • Levigated

  • Efflorescent

  • Hygroscopic

Erklärung

Frage 8 von 80

1

The following property is especially important in dermatologicals

Wähle eine der folgenden:

  • Rapid Disintegration

  • Content Uniformity

  • Nongrittiness of solid particles

  • Fast dissolution rate

Erklärung

Frage 9 von 80

1

Phenobartital divided powders have the advantage of

Wähle eine der folgenden:

  • Being dispensed in sifter-top containers

  • Spreading uniformly, and clinging to the skin upon application

  • Allowing physicians to prescribe a precise amount of the drug

  • Having no irritant properties when applied externally

Erklärung

Frage 10 von 80

1

Which of the following is FALSE regarding a dusting powder?

Wähle eine der folgenden:

  • Should flow easily, spread uniformly, and cling to the skin upon application

  • Would generally be dispensed in sifter-top containers

  • Must be able to have a systemic effect

  • Must be free from potential of causing local irritation

Erklärung

Frage 11 von 80

1

Which of the following is a natural emulsifying agent?

Wähle eine der folgenden:

  • Acacia

  • Brij

  • Benzakonium Chloride

  • Myrj

  • Sodium lauryl sulfate

Erklärung

Frage 12 von 80

1

The following powders when mixed are an example of a eutectic mixture

Wähle eine der folgenden:

  • Zinc oxide and glycerin

  • Phenol and talc powder

  • Camphor and menthol

  • Camphor and lactose

Erklärung

Frage 13 von 80

1

Metered inhalation aerosols containing micronized medicated powders typically have

Wähle eine der folgenden:

  • A particle size in the range of 18-26μm

  • A particle size in the range of 1-6μm

  • A particle size in the range of 12-18μm

  • A particle size in the range of 6-12μm

Erklärung

Frage 14 von 80

1

Which of the following is not a component of the Lacrimal Apparatus?

Wähle eine der folgenden:

  • Lacrimal Gland

  • Lacrimal Sac

  • Lacrimal Muscle

  • Lacrimal Ducts

Erklärung

Frage 15 von 80

1

Aqueous humor is produced by filtration of blood plasma in the region known as the:

Wähle eine der folgenden:

  • Choroid

  • Lacrimal Caruncle

  • Conjunctiva

  • Ciliary Body

Erklärung

Frage 16 von 80

1

Which of the following statements regarding the ophthalmic insert “Ocusert” is NOT true?

Wähle eine der folgenden:

  • Clinical acceptance of the device has been slow

  • It is a controlled delivery device for the drug pilocarpine

  • It is designed to dissolve completely in lacrimal fluids within a few days of insertion

  • It is more costly than traditional delivery systems such as solutions

Erklärung

Frage 17 von 80

1

Which layer(s) of the cornea offers the greatest barrier(s) to absorption into the eye for hydrophilic drugs?

Wähle eine der folgenden:

  • Endothelial layer

  • Epithelial layer

  • Stroma

  • b and c only

Erklärung

Frage 18 von 80

1

Cataracts are caused by

Wähle eine der folgenden:

  • clouding of the lens caused by clumping of crystallins.

  • loss of elasticity of the lens with age.

  • sloughing (peeling) of the posterior layers of the lens caused by various diseases

  • destruction of the cuboidal epithelial lining on the anterior surface of the lens.

Erklärung

Frage 19 von 80

1

To prevent possible corneal damage, ophthalmic formulations should be buffered in the pH range of:

Wähle eine der folgenden:

  • 4.5 to 10.5

  • 6.5 to 8.5

  • 3.5 to 11.5

  • 5.5 to 9.5

Erklärung

Frage 20 von 80

1

Which of the following is NOT an antioxidant that has been found appropriate for use in ophthalmic formulations?

Wähle eine der folgenden:

  • Sodium metabisulfite

  • Sodium Bisulfite

  • Thimerosal

  • Ethylenediaminetetraacetic acid

Erklärung

Frage 21 von 80

1

Particle size can influence:

Wähle eine der folgenden:

  • Penetrability of particles for inhalation (dry powder inhaler) for deposition deep in the respiratory tract.

  • Dissolution rate

  • Suspendability of suspensions

  • Uniformity of mixtures in powder dosage forms to ensure dose to dose content uniformity

  • All of the above

Erklärung

Frage 22 von 80

1

Below what pH will free phenobarbital begin to separate from a solution having an initial concentration of 2 g of sodium phenobarbital per 200 ml at 25 0C? The saturation solubility of phenobarbital is 0.005 M and the pKa =7.41 at 25 0C. Molecular weight of phenobarbital is 232 and sodium phenobarbital is 254.

Wähle eine der folgenden:

  • 8.45

  • 8.25

  • 8.35

  • 8.55

  • 8.65

Erklärung

Frage 23 von 80

1

The process of comminution by utilizing a SOLVENT that can be easily removed is termed:

Wähle eine der folgenden:

  • Geometric Dilution

  • Pulverization by intervention

  • Levigation

  • micronization

Erklärung

Frage 24 von 80

1

Which of the following is NOT an accurate characteristic of the rectum

Wähle eine der folgenden:

  • It is nonmotile in the resting state

  • It is approximately 15 to 20 cm in length

  • The mucosal lining contains Goblet cells which release collagen into the lumen.

  • When void of fecal matter it has a fluid content of 2 to 3 ml

Erklärung

Frage 25 von 80

1

Of the veins that drain the blood from the rectal area, which one(s) bypass the liver and deliver blood directly to the systemic circulation?

Wähle eine der folgenden:

  • The inferior and middle rectal veins

  • The inferior, middle and superior rectal veins

  • The inferior and superior rectal veins

  • The middle and superior rectal veins

Erklärung

Frage 26 von 80

1

The names of four drugs are given blow along with their corresponding density factors for cocoa butter.

A. Aminophylline (1.1)
B. Bismuth subnitrate (6.0)
C. Menthol (0.7)
D. Iodoform (4.0)

For which drug would the greatest weight be required in order to displace 1 gram of coca butter from a formulation?

Wähle eine der folgenden:

  • A

  • B

  • C

  • D

Erklärung

Frage 27 von 80

1

Which of the following is NOT an advantage of drug dosing via the rectal route?

Wähle eine der folgenden:

  • Drugs are not exposed to GI membrane enzymatic activity

  • It can be used for unconscious or debilitated patients

  • Absorption from the rectal area is more rapid and predictable than from other regions of the GI tract

  • Hepatic first-pass metabolism may be avoided partially or completely

Erklärung

Frage 28 von 80

1

The maximum amount of solid that can normally be incorporated into a suppository is ______ of the blank weight.

Wähle eine der folgenden:

  • 50%

  • 40%

  • 30%

  • 10%

Erklärung

Frage 29 von 80

1

You desire to administer a drug rectally in order to obtain a rapid onset of action. Which of the following suppositories would you use?

Wähle eine der folgenden:

  • An oleaginous base containing the unionized form of the drug

  • An oleaginous base containing a salt form of the drug

  • A water miscible base containing the unionized form of the drug

  • A water miscible base containing a salt form of the drug

Erklärung

Frage 30 von 80

1

You are preparing a cocoa butter suppository and have added ingredients that have lowered the melting point below that of room temperature. In order to elevate the melting point of the mixture you will add:

Wähle eine der folgenden:

  • Beeswax

  • Chloral hydrate

  • Menthol

  • Camphor

Erklärung

Frage 31 von 80

1

The physical characteristics of Polyethylene glycol (PEG) polymers change with size. At what molecular weight do these polymers change from liquid to solid?

Wähle eine der folgenden:

  • 100

  • 1000

  • 10000

  • 500

Erklärung

Frage 32 von 80

1

You prepared and recorded the disintegration time for salicylic acid capsules in different pH media. Which statement is TRUE?

Wähle eine der folgenden:

  • The disintegration time of salicylic acid capsules was shortest in pH 7.4 buffer

  • The disintegration time of salicylic acid capsules was shortest in water

  • The disintegration time of salicylic acid capsules is longest in pH 1.2 buffer

  • The disintegration time of salicylic acid capsules was shortest in pH 1.2 buffer

Erklärung

Frage 33 von 80

1

Sedimentation rate of particles in suspension decreases with

Wähle eine der folgenden:

  • Increase in the viscosity of dispersed phase

  • Increase in the particle size

  • Decrease in the viscosity of dispersed phase

  • Decrease in the viscosity of dispersion medium

  • Increase in the viscosity of dispersion medium

Erklärung

Frage 34 von 80

1

Shelf-life is generally based on the time when the active drug is greater than ______ of the labeled.

Wähle eine der folgenden:

  • 99%

  • 95%

  • 90%

  • 85%

Erklärung

Frage 35 von 80

1

The pre-exponential factor, A, of the Arrhenius equation is representative of:

Wähle eine der folgenden:

  • the probability that any given collision will result in a reaction

  • the total number of collisions per unit time, whether they lead to a reaction or not

  • the fraction of molecules in the reaction that have energies higher than that of the activation energy, Ea.

  • the total number of collisions per unit time that result in a reaction

Erklärung

Frage 36 von 80

1

A solution has a shelf-life of 10 hours at a temperature of 35oC. Use the Q10 method to estimate the shelf-life if the solution is stored in a refrigerator at 5oC. Use a value of 3 for Q10.

Wähle eine der folgenden:

  • 30 hours

  • 90 hours

  • 150 hours

  • 270 hours

Erklärung

Frage 37 von 80

1

You are working in a pharmacy and are compounding a solid formulation in which the manufactured drug is the source of the active ingredient. The product’s expiration date is 16 months from today. What Beyond Use Date will you assign this formulation?

Wähle eine der folgenden:

  • 6 months

  • 4 months

  • 30 days

  • 14 days

Erklärung

Frage 38 von 80

1

A pharmacist compounding a fine dusting powder typically would triturate the components of the formulation in a mortar with a pestle and subsequently pass the mixture through a (n):

Wähle eine der folgenden:

  • #8 mesh sieve

  • #80 mesh sieve

  • #20 mesh sieve

  • #60 mesh sieve

Erklärung

Frage 39 von 80

1

Soft gelatin capsules are made of gelatin

Wähle eine der folgenden:

  • to which polysorbate 80 has been added

  • to which glycerin has been added

  • to which mineral oil has been added

  • to which camphor has been added

Erklärung

Frage 40 von 80

1

Which one of the following has the highest aqueous solubility?

Wähle eine der folgenden:

  • C6H5OH

  • C6H4(OH)2

  • C6H3Cl3

  • C6H5Cl

  • C6H3(OH)3

Erklärung

Frage 41 von 80

1

Which of the following is NOT a major factor affecting solubility?

Wähle eine der folgenden:

  • Temperatur

  • pH of the solution

  • Polarity of the solvent

  • Polarity of the solute

  • Moleculare weight of the solvent

Erklärung

Frage 42 von 80

1

Active transport processes include all of the following except for which one?

Wähle eine der folgenden:

  • Active transport of drug molecules may be saturated at high drug concentrations

  • Active transport moves drug molecules against a concentration gradient

  • active transport requires energy

  • Active transport follows fick's law of diffusion

  • Active transport is a carrier mediated transport system

Erklärung

Frage 43 von 80

1

When comparing an amorphous form of a drug to a crystalline form of a drug:

Wähle eine der folgenden:

  • Amorphous forms dissolve more quickly

  • crystalline forms are more pharmacologically active

  • Metastable forms are more clinically effective

  • Amorphous forms are more chemically stable

Erklärung

Frage 44 von 80

1

According to the FDA Biopharmaceutics classification system, the class III type compounds are those with:

Wähle eine der folgenden:

  • High solubility, low permiability

  • High solubility, high permeability

  • low solubility, low permeability

  • low solubility, high permeability

Erklärung

Frage 45 von 80

1

What imparts the pink color to Calamine USP

Wähle eine der folgenden:

  • FD&C red no3

  • Carmine

  • Zinc Oxide

  • Ferric Oxide

Erklärung

Frage 46 von 80

1

Chemicals of indeterminate quality would be labeled as

Wähle eine der folgenden:

  • USP/NF

  • ACS Reagent

  • Chemically Pure

  • Technical or commercial

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Frage 47 von 80

1

this grade of ingredients is : High purity; conforms to minimum specifications set by the Reagent Chemicals Committee of the American Chemicals Society

Wähle eine der folgenden:

  • USP/NF

  • ACS Reagent

  • Chemically Pure

  • Technical or commercial

Erklärung

Frage 48 von 80

1

This grade of chemicals is :More refined than technical or commercial grade but still of unknown quality

Wähle eine der folgenden:

  • USP/NF

  • ACS Reagent

  • Chemically Pure

  • Technical or commercial

Erklärung

Frage 49 von 80

1

This grade of chemicals : Meets the minimum purity standards; and conforms to tolerances set by the United States Pharmacopeia/National Formulary for contaminants dangerous to health

Wähle eine der folgenden:

  • USP/NF

  • ACS Reagent

  • Chemically Pure

  • Technical or commercial

Erklärung

Frage 50 von 80

1

Which of the following is NOT true for crystal polymorphs?

Wähle eine der folgenden:

  • May have different solubility

  • May have different dissolution rates

  • May have different physical and chemical stability

  • May have different chemical structures

  • May have different melting points

Erklärung

Frage 51 von 80

1

Which condition usually increases the rate of drug dissolution from a tablet?

Wähle eine der folgenden:

  • Use of enteric coating

  • Use of the ionized or salt of the drug

  • Use of the free acid or free base form of the drug

  • Decrease surface area of the drug

  • Increase particle size of the drug

Erklärung

Frage 52 von 80

1

Which of the following is FALSE regarding inconsistencies in dissolution rates?

Wähle eine der folgenden:

  • Dose units within a batch typically give consistent dissolution results

  • dose units within a batch typically give inconsistent dissolution results

  • dissolution inconsistencies can occur between batches or products from the same manufacturer

  • Dissolution inconsistencies can occur between batches or products from different manufacturers

Erklärung

Frage 53 von 80

1

All of the following factors depend on the rate of active drug dissolution within the gastrointestinal content EXCEPT:

Wähle eine der folgenden:

  • Fraction of the administered dose that is bioavailable

  • Time after administration until therapeutic action begins

  • Intensity of systemic pharmacologic effects

  • site of action in the body

Erklärung

Frage 54 von 80

1

Which of the following is FALSE regarding the need for a dosage form?

Wähle eine der folgenden:

  • To provide for a safe and convenient delivery of accurate dosage

  • To conceal the bitter, salty, or offensive taste, or odor of a drug

  • To protect the drug substance from the destructive influences of atmospheric oxygen or humidity

  • To enhance the dissolution rate of a drug substance.

Erklärung

Frage 55 von 80

1

What is the minimum weighable quantity with no more than 5% error for a balance with a sensitivity requirement of 6mg?

Wähle eine der folgenden:

  • 300mg

  • 30mg

  • 120mg

  • 3mg

Erklärung

Frage 56 von 80

1

The Prescription balance needed for weighing chemicals is currently designated as a class ____ balance by the national bureau of standards

Wähle eine der folgenden:

  • I

  • II

  • III

  • P

  • Q

Erklärung

Frage 57 von 80

1

A Class III balance should have a sensitivity requirement of:

Wähle eine der folgenden:

  • 10mg

  • 5mg

  • 6mg

  • 2mg

Erklärung

Frage 58 von 80

1

All of the following are part of the compendial requirements for tablets according to USP/NF EXCEPT:

Wähle eine der folgenden:

  • Tablet Content Uniformity test

  • Tablet Weight Variation Test

  • Tablet Thickness Test

  • Tablet Dissolution test

  • Tablet Disintegration test

Erklärung

Frage 59 von 80

1

At the first sign of Angina attack the patient should reach out and:

Wähle eine der folgenden:

  • Apply Nitro ointment to the chest

  • Apply a Nitro patch to the skin

  • Swallow a sustained release 2.5 mg Nitro capsule

  • Place a sublingual Nitro tablet under the tongue

Erklärung

Frage 60 von 80

1

The requirements for tablet content uniformity are met if the amount of active ingredient in each dose unit is within the range:

Wähle eine der folgenden:

  • 95-105% of the label claim and the standard deviation less than 6%

  • 90-110% of the label claim with a standard deviation less than 6%

  • 85-115% of the label claim and a standard deviation of less than 6%

  • 80-120% of the label claim and a standard deviation of less than 6%

Erklärung

Frage 61 von 80

1

Which of the following excipients can NOT be used in the formulation of tetracycline antibiotics?

Wähle eine der folgenden:

  • Microcrystalline cellulose

  • starch

  • talc powder

  • Calcium Phosphate

Erklärung

Frage 62 von 80

1

The partial or complete separation of the top or bottom crowns of a tablet from the main body of the tablet is known as

Wähle eine der folgenden:

  • Lamination

  • Picking

  • Slugging

  • Capping

  • Mottling

Erklärung

Frage 63 von 80

1

All of the following statements reflect the importance of in-vitro dissolution testing EXCEPT:

Wähle eine der folgenden:

  • It guides the formulation and product development towards product optimization

  • It is a requirement for regulatory approval of marketed products registered with the FDA

  • It is important for guiding the testing of class I BCS type compounds

  • Consistent dissolution testing ensures bioequivalence between batch to batch

Erklärung

Frage 64 von 80

1

Which of the following organic esters is commonly used in enteric coating of solid dosage forms?

Wähle eine der folgenden:

  • Phosphate

  • Tannate

  • Acrylate

  • Phthalate

  • Succinate

Erklärung

Frage 65 von 80

1

Which of the following is NOT a candidate for an extended release product?

Wähle eine der folgenden:

  • Drug with narrow therapeutic index

  • Drug administered in relatively small doses

  • Drug that exhibits neither slow nor fast rate of excretion

  • Drug must be absorbed/excreted at a moderate rate

  • Drug used in the treatment of chronic conditions

Erklärung

Frage 66 von 80

1

Which of the following products is an osmotic oral release system?

Wähle eine der folgenden:

  • Spansule Capsule

  • Glucotrol XL

  • Micro-K10 extencaps

  • Desoxyn gradument

Erklärung

Frage 67 von 80

1

What is a feature of Procardia XL tablets?

Wähle eine der folgenden:

  • Tablet remains intact in the stool

  • Rapid disintegration to quickly release components

  • Protect the drug from the acidic stomach environment

  • Fast dissolving of the outer core of the tablet allowing the drug dose to be immediately available

  • Orally disintegrating tablet which releases in the mouth within 1 minute

Erklärung

Frage 68 von 80

1

Tablets that are characterized by disintegrating or dissolving in the mouth within 1 minute are called:

Wähle eine der folgenden:

  • Effervescent Tablets

  • Enteric coated Tablets

  • Modified release tablets

  • Immediate release tablets

  • Rapidly dissolving Tablets

Erklärung

Frage 69 von 80

1

Which chapter in the USP/NF provides for the procedures and requirements for nonsterile type of compounding?

Wähle eine der folgenden:

  • 1075

  • 1163

  • 795

  • 797

  • 1160

Erklärung

Frage 70 von 80

1

In which of the following kinetic processes does the value of the half-life remain constant irrespective of time or amount of reactant?

Wähle eine der folgenden:

  • Second order

  • First order

  • Zero order

  • All of the above

Erklärung

Frage 71 von 80

1

You prepare 2 plots. One you plot ln(Y) vs time. One you plot log(Y) vs time. Both plots yield straight lines. For which of these plots is the negative slope the steepest?

Wähle eine der folgenden:

  • Plot of ln(Y) vs time

  • Plot of Log(Y) vs time

  • The slopes of the two lines are the same

  • The slopes depend on the amounts of Y present initially

Erklärung

Frage 72 von 80

1

The rate constant (k) is 0.08 moles/minute. If we begin the rxn with 10 moles of Y, how much Y will disappear in the first minute of the reaction

Wähle eine der folgenden:

  • 0.08 moles

  • 0.4 moles

  • 0.8 moles

  • 10 moles

Erklärung

Frage 73 von 80

1

A ________ Dispersion has particles that range in the diameter from 1nm to 0.5micron and that are visible in an electron microscope but not an ordinary optical microscope

Wähle eine der folgenden:

  • Molecular

  • Cellular

  • Coarse

  • Colloidal

Erklärung

Frage 74 von 80

1

Which of the following types of compounds would be least susceptible to degradation via oxidation

Wähle eine der folgenden:

  • Alcohols

  • Esters

  • Aldehydes

  • Molecules with unsaturated linkages

Erklärung

Frage 75 von 80

1

The most important cause of drug decomposition is

Wähle eine der folgenden:

  • Oxidation

  • Reduction

  • hydrolysis

  • condensation

Erklärung

Frage 76 von 80

1

How many half lives would it take for 90% of any initial concentration of a drug to disappear from a reaction vessel, assuming first order chemical kinetics?

Wähle eine der folgenden:

  • 6.7

  • 4.3

  • 2.7

  • 3.3

Erklärung

Frage 77 von 80

1

In which of the following kinetic processes is the rate constant the same as the rate?

Wähle eine der folgenden:

  • Zero-order

  • Second-order

  • Michaelis-Menten

  • first-order

Erklärung

Frage 78 von 80

1

When the concentration of the drug (Y) is low (Y<<K), the process will best be described by:

Wähle eine der folgenden:

  • Zero-order

  • First-order

  • Second-order

  • Unimolecularity

Erklärung

Frage 79 von 80

1

An Inert system is:

Wähle eine der folgenden:

  • Thermodynamically stable and kinetically stable

  • Thermodynamically unstable and kinetically unstable

  • Thermodynamically stable and kinetically unstable

  • Thermodynamically unstable and kinetically stable

Erklärung

Frage 80 von 80

1

Which kinetic process is linear

Wähle eine der folgenden:

  • Zero-order

  • First-order

  • Both A and B

  • Neither a nor B

Erklärung

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