Esther  Yook
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assessment 1.2

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Esther  Yook
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Assessment 1.2 Turning point

Frage 1 von 49

1

Which of the following statements is not true regarding the need for a dosage form:

Wähle eine der folgenden:

  • To protect the drug substance from the destructive influences of atmospheric oxygen or humidity

  • To conceal the bitter, salty, or offensive taste or odor of a drug substance.

  • To avoid drug-drug interactions thus providing greater clinical efficacy.

  • To provide for a safe and convenient delivery of accurate dosage

Erklärung

Frage 2 von 49

1

Which of the following is not true for different crystal polymorphs

Wähle eine der folgenden:

  • May have different solubility

  • May have different dissolution rate

  • May have different chemical structure

  • May have different melting point

  • May have different physical and chemical stability

Erklärung

Frage 3 von 49

1

Biopharmaceutics Classification System is used to classify drugs based on

Wähle eine der folgenden:

  • Melting point and pH

  • Aqueous solubility and bioavailability

  • Aqueous solubility and dissolution rate

  • Intestinal permeability and particle size

  • Dissolution rate and Intestinal permeability

  • Dissolution rate, aqueous solubility and intestinal permeability

Erklärung

Frage 4 von 49

1

When being incorporated into ointment bases, fine powders such as calamine and zinc oxide are often wetted and smoothed with mineral oil. What name is given to this process

Wähle eine der folgenden:

  • Attrition

  • Levigation

  • Milling (pulverizing /grinding)

  • Pulverization by intervention

  • trituration

Erklärung

Frage 5 von 49

1

Which factor does not affect the rate and extent of absorption from immediate release solid dosage froms

Wähle eine der folgenden:

  • Solubility

  • Dissolution

  • Appearance

  • Permeability

  • Particle size

Erklärung

Frage 6 von 49

1

Which of the following is NOT a reason for the extemporaneous preparation of a dosage form

Wähle eine der folgenden:

  • Shortage of a marketed dosage form

  • Need a liquid dosage form for treating a pediatric patient

  • Medication is not commercially available

  • Geriatric patient is able to swallow solid oral dosage form

  • Patient may be allergic to preservative or dyes contained in the drug product

Erklärung

Frage 7 von 49

1

Which of the following is used in tablet formulations to reduce friction during tablet compression

Wähle eine der folgenden:

  • Talc powder (Glidant)

  • Lactose (Diluents or Fillers)

  • Gum Acacia (Binders)

  • Magnesium stearate

  • Starch (Disintegrant)

  • Sodium carboxymethyl cellulose (Coatings)

Erklärung

Frage 8 von 49

1

Before placing a patient onto IV fat emulsions, the pharmacist should confirm that the patient does not have:

Wähle eine der folgenden:

  • Egg allergies

  • Sensitivities to bisulfate

  • Milk intolerance

  • Lactose intolerance

  • Sensitivities to tartrazine

Erklärung

Frage 9 von 49

1

Based on the pH partition theory, weakly acidic drugs are most likely to be absorbed from the stomach because:

Wähle eine der folgenden:

  • The drugs will exist primarily in the unionized, more lipid-soluble form

  • The drugs will exist primarily in the ionized, more water soluble form

  • Weak acids are more soluble in acid media

  • The ionic form of the drug facilitates dissolution

  • Weak acids will further lower the pH

Erklärung

Frage 10 von 49

1

The passage of drug molecules from a region of high drug concentration to a region of low drug concentration is known as:

Wähle eine der folgenden:

  • Active transport

  • Bioavailability

  • Biopharmaceutics

  • Simple diffusion

  • Pinocytosis

Erklärung

Frage 11 von 49

1

A prime consideration in biopharmaceutics is a drug’s “biovavailability” which refers to the relative amount of drug that reaches the :

Wähle eine der folgenden:

  • small intestine

  • stomach

  • Systemic circulation

  • Liver

  • kidneys

Erklärung

Frage 12 von 49

1

Which of the following is not true if a physician would like the patient to use a generic product equivalent to the brand-name product

Wähle eine der folgenden:

  • Both the generic and the brand-name drug products must be pharmaceutical equivalents

  • Both the generic and the brand-name drug products must have the same bioavailability

  • Both the generic and the brand-name drug products must have the same excipients

  • Both the generic and the brand-name drug products must have identical amounts of the API

Erklärung

Frage 13 von 49

1

Dosage forms of nitroglycerin that are minimally affected by the First-Pass effect include:
I. Intravenous
II. Transdermal patches
III. Sublingual tablets

Wähle eine der folgenden:

  • I only

  • III only

  • I and II only

  • II and III only

  • I, II and III

Erklärung

Frage 14 von 49

1

Which of the following is not an advantage of a tablet dosage form:

Wähle eine der folgenden:

  • Accurate dosage/minimum variability

  • Easiest/cheapest to package and ship

  • Swallowing

  • Patient acceptance

  • Convenience (light and compact)

  • Tamper resistant

Erklärung

Frage 15 von 49

1

Which of the following IVIVC classes is the intestinal permeability the rate limiting step in systemic drug absorption?

Wähle eine der folgenden:

  • Class IV

  • Class II

  • Class III

  • Class I

Erklärung

Frage 16 von 49

1

Which of the following is the primary purpose of orally disintegrating tablet:

Wähle eine der folgenden:

  • Avoid exposure of content to stomach acid

  • Avoid hepatic first-pass effect

  • Increase drug bioavailability

  • Increase ease of swallowing

Erklärung

Frage 17 von 49

1

Which of the following organic esters is commonly used in enteric coating of solid dosage forms:

Wähle eine der folgenden:

  • Phthalate

  • Tannate

  • Succinate

  • Acrylate

  • Phosphate

Erklärung

Frage 18 von 49

1

Which of the following tablet dosage forms avoids the hepatic first-pass effects?

Wähle eine der folgenden:

  • Enteric coating

  • Instantly disintegrating

  • Chewable

  • Sublingual

  • Film coated

Erklärung

Frage 19 von 49

1

The partial or complete separation of the top or bottom crowns of a tablet from the main body of the tablet is known as:

Wähle eine der folgenden:

  • Lamination

  • Slugging

  • Capping

  • Mottling

  • Picking

Erklärung

Frage 20 von 49

1

False statement regarding the function of excipients used in tablet manufacture

Wähle eine der folgenden:

  • Binders promote granulation during the wet granulation process

  • Glidants help promote the flow of the tablet granulation during manufacture

  • Lubricants help patient swallow the tablets

  • Disintegrants are added to tablet formulations to facilitate the disintegration when the tablet contacts water in the gastrointestinal tract.

Erklärung

Frage 21 von 49

1

Which manufacturing variables would be likely to affect the dissolution of a prednisone tablet in the body?

Wähle eine der folgenden:

  • The amount and type of binder

  • The amount and type of disintegrant added

  • The force of compression used during tableting

  • All of the above

Erklärung

Frage 22 von 49

1

If the preparation is compounded from USP/NF ingredients,

Wähle eine der folgenden:

  • a beyond-use date of 3 months is appropriate

  • a beyond-use date of 6 months is appropriate

  • a beyond-use date of 9 months is appropriate

  • a beyond-use date of 12 months is appropriate

Erklärung

Frage 23 von 49

1

Inconsistent in-vitro dissolution test results for the same solid oral dosage form of the same drug and strength generally indicate differences in all of the following EXCEPT:

Wähle eine der folgenden:

  • Dose units containing the same amount of drug but from different manufacturing process by the same manufacturer

  • Dose units from different batches or lots by the same manufacturer

  • Dose units from different manufacturers

  • Dose units from the same batch or lot

Erklärung

Frage 24 von 49

1

The United States Pharmacopeia (USP) content uniformity test for tablets is used to ensure which quality?

Wähle eine der folgenden:

  • Bioequivalence

  • Dissolution

  • Potency

  • Purity

  • Toxicity

Erklärung

Frage 25 von 49

1

Which of the following is most likely to occur with high speed machines that produce ≥ 10,000 tablets per minute?

Wähle eine der folgenden:

  • Granulation underfilling

  • Excessive tablet hardness

  • Inconsistent tablet weights

  • Capping

Erklärung

Frage 26 von 49

1

United Stated Pharmacopeia (USP) tests to ensure the quality of drug products in tablet form include all of the following EXCEPT:

Wähle eine der folgenden:

  • Disintegration

  • Dissolution

  • Hardness and friability

  • Content uniformity

  • Weight variation

Erklärung

Frage 27 von 49

1

Which of the following is false regarding dusting powders

Wähle eine der folgenden:

  • Dusted on the skin , no systemic action

  • Must be homogenous, free from potential of causing local irritation

  • Should flow easily, spread uniformly, and cling to the skin upon application

  • Have a systemic action

  • Generally dispensed in sifter-top containers

Erklärung

Frage 28 von 49

1

Which of the following drug substance property is important for capsule size selection

Wähle eine der folgenden:

  • Bulk density

  • Particle size

  • Drug substance solubility

  • Melting point

Erklärung

Frage 29 von 49

1

Which of the following is not part of Capsule Quality Control program

Wähle eine der folgenden:

  • Drug Content

  • Fill Weight

  • Disintegration

  • Dissolution

  • Hardness

  • Stability

  • Moisture permeation test

Erklärung

Frage 30 von 49

1

The community pharmacist intends to prepare a fine dusting powder by triturating the components of the formulation in a mortar with a pestle and subsequently passing the mixture through a:

Wähle eine der folgenden:

  • 80 mesh sieve

  • 60 mesh sieve

  • 20 mesh sieve

  • 8 mesh sieve

Erklärung

Frage 31 von 49

1

Which of the following can be influenced by Particle Size:

Wähle eine der folgenden:

  • Dissolution rate

  • Suspendability of suspensions

  • Uniformity of mixtures in powder dosage forms to ensure dose to dose content uniformity

  • Penetrability of particles for inhalation (dry powder inhaler) for deposition deep in the respiratory tract.

  • Nongrittiness of solid particles for ointments, creams, gels

  • All of the above

Erklärung

Frage 32 von 49

1

When of the following drug substances will soften or liquefy when grinded

Wähle eine der folgenden:

  • Lactose

  • Starch

  • Camphor

  • Magnesium stearate

  • Sodium carboxy methylcellulose

Erklärung

Frage 33 von 49

1

Which of the following is NOT an accurate characteristic of the rectum?

Wähle eine der folgenden:

  • It is approximately 15 – 20 cm in length

  • When void of fecal matter it has a fluid content of 2-3 ml

  • It is non-motile in resting state

  • The mucosal lining contains Goblet cells which release collagen into the lumen

Erklärung

Frage 34 von 49

1

Of the veins that drain the blood from the rectal area, which one(s) bypass the liver and deliver blood directly to the systemic circulation?

Wähle eine der folgenden:

  • The inferior and middle rectal veins

  • The inferior and superior rectal veins

  • The middle and superior rectal veins

  • The inferior, middle and superior rectal veins

Erklärung

Frage 35 von 49

1

Which of the following is NOT an advantage of drug dosing via rectal route?

Wähle eine der folgenden:

  • It can be used for unconscious patients

  • Rapid and predictable absorption as compared to other regions of GI tract

  • Hepatic first-pass metabolism may be avoided partially or completely

  • Drugs are not exposed to GI membrane enzymatic activity

Erklärung

Frage 36 von 49

1

The maximum amount of solid that can normally be incorporated into a suppository is ______ of the blank weight.

Wähle eine der folgenden:

  • 20%

  • 30%

  • 40%

  • 50%

Erklärung

Frage 37 von 49

1

While preparing a cocoa butter suppository with other ingredients, the melting point is lowered below that of room temperature. To elevate the melting point of the mixture you will add (select all that apply):

Wähle eine der folgenden:

  • Chloral hydrate

  • Menthol

  • Camphor

  • Beeswax

Erklärung

Frage 38 von 49

1

Above what molecular weight do PEG polymers change from liquid to solid ?

Wähle eine der folgenden:

  • 100

  • 500

  • 1000

  • 5000

Erklärung

Frage 39 von 49

1

The density factors of four drugs for cocoa butter are given below. For which drug would the greatest weight be required in order to displace 1 g of cocoa butter from a formulation ?

Wähle eine der folgenden:

  • Aminophylline (1.1)

  • Bismuth subnitrate (6.0)

  • Menthol (0.7)

  • Iodoform (4.0)

Erklärung

Frage 40 von 49

1

Pharmacist patient-counseling points for proper use of rectal suppositories includes all of the following EXCEPT:

Wähle eine der folgenden:

  • PEG suppositories should not be stored in polystyrene vials because they react with polystyrene.

  • Before insertion PEG suppositories should be moistened with water.

  • Cocoa butter suppositories should be frozen first and then immediately inserted.

  • Suppositories should be inserted in an adult up to the first knuckle depth (~1 inch).

Erklärung

Frage 41 von 49

1

Compared to the oral route of administration, all of the following are advantages of the rectalroute of administration EXCEPT:

Wähle eine der folgenden:

  • An effective route for treating nausea and vomiting.

  • Drugs are activated by the pH in the rectum to increase absorption.

  • Useful for administering drugs that cause stomach irritation.

  • Avoids first-pass hepatic deactivation.

Erklärung

Frage 42 von 49

1

When using cocoa butter suppositories, which of the following drugs will result in the slowest drug release?

Wähle eine der folgenden:

  • Ionized hydrophilic drug

  • Unionized hydrophilic drug

  • Unionized lipophilic drug

  • Salt form of the drug

Erklärung

Frage 43 von 49

1

Which of the following is NOT a component of the Lacrimal Apparatus?

Wähle eine der folgenden:

  • Lacrimal gland

  • Lacrimal ducts

  • Lacrimal sac

  • Lacrimal muscle

Erklärung

Frage 44 von 49

1

Which layer(s) of the cornea offers the greatest barrier(s) to absorption into the eye for hydrophilic drugs?

Wähle eine der folgenden:

  • Epithelial layer

  • Stroma

  • Endothelial layer

  • 2 and 3 only

Erklärung

Frage 45 von 49

1

To prevent possible corneal damage, ophthalmic formulations should be buffered in the pH range of:

Wähle eine der folgenden:

  • 3.5 to 11.5

  • 4.5 to 10.5

  • 5.5 to 9.5

  • 6.5 to 8.5

Erklärung

Frage 46 von 49

1

Which of the following is NOT an antioxidant that has been found appropriate for use in ophthalmic formulations?

Wähle eine der folgenden:

  • Ethylenediaminetetra-acetic acid

  • Sodium Bisulfite

  • Thimerosal

  • Sodium metabisulfite

Erklärung

Frage 47 von 49

1

pH buffers for ophthalmic solutions are designed and intended to provide all of the following EXCEPT:

Wähle eine der folgenden:

  • Patient comfort

  • Decreasing systemic absorption

  • Increasing drug stability

  • Increasing drug solubility

Erklärung

Frage 48 von 49

1

The respiratory region of the nasal cavity is believed to be most suitable for drug delivery because:

Wähle eine der folgenden:

  • It is poorly supplied with blood vessels

  • It has a relatively large surface area

  • It contains stratified keratinized epithelial cells

  • It directly drains into the lungs

Erklärung

Frage 49 von 49

1

All of the following statements about nasal drug delivery are true EXCEPT:

Wähle eine der folgenden:

  • Nasal bioavailability of a drug is typically lower than intravenous bioavailability

  • Nasally administered anesthetic agents can get absorbed by the olfactory region

  • Nasally absorbed drugs can bypass extensive hepatic metabolism

  • Nasal congestion does not affect the bioavailability of the drug

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